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Ift88 Gene Detail
Summary
  • Symbol
    Ift88
  • Name
    intraflagellar transport 88
  • Synonyms
    fxo, IFT88, Oak Ridge polycystic kidneys, orpk, polaris, Tg737, Tg737Rpw, TgN737Rpw, Ttc10
  • Feature Type
    protein coding gene
  • IDs
    MGI:98715
    NCBI Gene: 21821
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:57661519-57755393 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2042 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98715
 protein coding gene Chr14:57661519-57755393 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021406
 protein coding gene Chr14:51604748-51708778 (+)
A/J MGP_AJ_G0021367
 protein coding gene Chr14:50586475-50682126 (+)
AKR/J MGP_AKRJ_G0021342
 protein coding gene Chr14:52355060-52456875 (+)
BALB/cJ MGP_BALBcJ_G0021370
 protein coding gene Chr14:50533498-50628789 (+)
C3H/HeJ MGP_C3HHeJ_G0021149
 protein coding gene Chr14:52010189-52108620 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021809
 protein coding gene Chr14:54167350-54261438 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019349
 protein coding gene Chr14:48673039-48763857 (+)
CAST/EiJ MGP_CASTEiJ_G0020667
 protein coding gene Chr14:48347240-48441551 (+)
CBA/J MGP_CBAJ_G0021116
 protein coding gene Chr14:55747675-55868441 (+)
DBA/2J MGP_DBA2J_G0021237
 protein coding gene Chr14:50265047-50358910 (+)
FVB/NJ MGP_FVBNJ_G0021218
 protein coding gene Chr14:49649484-49746793 (+)
LP/J MGP_LPJ_G0021312
 protein coding gene Chr14:52651957-52751712 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021246
 protein coding gene Chr14:55119308-55223180 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021833
 protein coding gene Chr14:51509587-51614162 (+)
PWK/PhJ MGP_PWKPhJ_G0020410
 protein coding gene Chr14:46801101-46897264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020243
 protein coding gene Chr14:47575713-47674168 (+)
WSB/EiJ MGP_WSBEiJ_G0020719
 protein coding gene Chr14:51829999-51928243 (+)



Homology
more
  • Human Ortholog
    IFT88, intraflagellar transport 88
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT88, intraflagellar transport 88
  • Synonyms
    D13S1056E, DAF19, hTg737, TG737, TTC10
  • Links
    NCBI Gene ID: 8100
    neXtProt AC: NX_Q13099
    UniProt: Q13099

  • Chr Location
    13q12.11; chr13:20567138-20691444 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ift88 mouse models

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    111 phenotypes from 7 alleles in 19 genetic backgrounds
    15 phenotypes from multigenic genotypes
    188 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    68
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    63
  • cDNA Data
    35
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21821 NCBI Gene Model | MGI Sequence Detail 93875 C57BL/6J ±  kb
    transcript NM_001404396 RefSeq | MGI Sequence Detail 3124 ZRU/MplStud  
    polypeptide Q61371 UniProt | EBI | MGI Sequence Detail 824 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 6
      cDNA 37
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15052, MGI:2145834
    References
    more
    • Summaries
      All 306
      Developmental Gene Expression 71
      Diseases 8
      Gene Ontology 68
      Phenotypes 188
    • Earliest
      J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
    • Latest
      J:354197 Dumoulin A, et al., A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance. Development. 2024 Sep 1;151(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory