Tgm3 MGI Mouse Gene Detail - MGI:98732 - transglutaminase 3, E polypeptide

Symbol

Tgm3
Name

transglutaminase 3, E polypeptide
Synonyms

TG E, we

Feature Type

protein coding gene
IDs

MGI:98732
NCBI Gene: 21818
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:129854269-129892319 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.19 cM
Mapping Data

35 experiments

SNPs within 2kb

1230 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98732	protein coding gene	Chr2:129829700-129892319 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026493	protein coding gene	Chr2:133429056-133471557 (+)
A/J	MGP_AJ_G0026457	protein coding gene	Chr2:128049452-128088124 (+)
AKR/J	MGP_AKRJ_G0026432	protein coding gene	Chr2:131708223-131747835 (+)
BALB/cJ	MGP_BALBcJ_G0026469	protein coding gene	Chr2:128395684-128433973 (+)
C3H/HeJ	MGP_C3HHeJ_G0026212	protein coding gene	Chr2:132172555-132210559 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026914	protein coding gene	Chr2:137579521-137626156 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024291	protein coding gene	Chr2:122798219-122836954 (+)
CAST/EiJ	MGP_CASTEiJ_G0025673	protein coding gene	Chr2:132415223-132454521 (+)
CBA/J	MGP_CBAJ_G0026192	protein coding gene	Chr2:142676634-142717316 (+)
DBA/2J	MGP_DBA2J_G0026326	protein coding gene	Chr2:127441830-127480077 (+)
FVB/NJ	MGP_FVBNJ_G0026290	protein coding gene	Chr2:126059987-126098476 (+)
LP/J	MGP_LPJ_G0026431	protein coding gene	Chr2:133692893-133734336 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026310	protein coding gene	Chr2:146538957-146579421 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026969	protein coding gene	Chr2:131688775-131728876 (+)
PWK/PhJ	MGP_PWKPhJ_G0025409	protein coding gene	Chr2:126988843-127027580 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025211	protein coding gene	Chr2:130807808-130846902 (+)
WSB/EiJ	MGP_WSBEiJ_G0025747	protein coding gene	Chr2:132617077-132660224 (+)

Human Ortholog

TGM3, transglutaminase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TGM3, transglutaminase 3
Synonyms

TGE, UHS2
Links

HGNC:11779

NCBI Gene ID: 7053

neXtProt AC: NX_Q08188

UniProt: Q08188
Chr Location

20p13; chr20:2296001-2341079 (+) GRCh38

MGI Vertebrate Homology

Tgm3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TGM3
Protein SuperFamily

TGM_EBP42
Gene Tree

Tgm3

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Phenotype Summary

17 phenotypes from 7 alleles in 7 genetic backgrounds
12 phenotypes from multigenic genotypes
4 images
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Spontaneous

4
Targeted

4
Genomic Mutations

2 involving Tgm3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for an ENU or null mutation exhibit rough-looking, curly hair. Null mutants display delayed skin barrier formation, loss of vibrissae, and brittle hairs.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1115
Tissues

197
cDNA Data

22
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tgm3l.4, tgm3l.8

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All Sequences

36
RefSeq

8
UniProt

1
CCDS

CCDS38240.1

Ensembl

ENSMUSG00000027401 (Evidence)
NCBI Gene

21818

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027401	Ensembl Gene Model \| MGI Sequence Detail	38051	C57BL/6J	± kb
transcript	ENSMUST00000110299	Ensembl \| MGI Sequence Detail	4135	Not Applicable
polypeptide	ENSMUSP00000105928	Ensembl \| MGI Sequence Detail	693	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016294 protein-glutamine gamma-glutamyltransferase E

(term hierarchy)
EC

2.3.2.13
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR038765 Papain-like cysteine peptidase superfamily

IPR023608 Protein-glutamine gamma-glutamyltransferase, animal

IPR050779 Protein-glutamine gamma-glutamyltransferases

IPR013808 Transglutaminase, active site

IPR008958 Transglutaminase, C-terminal

IPR036238 Transglutaminase, C-terminal domain superfamily

IPR002931 Transglutaminase-like

IPR036985 Transglutaminase-like superfamily

IPR001102 Transglutaminase, N-terminal
GlyGen

Q08189 1 site, 1 O-linked glycan (1 site)

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All nucleic 26

cDNA 22

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-15074, MGD-MRK-15431, MGI:2139112, MGI:98947

Summaries

All 89

Developmental Gene Expression 13

Gene Ontology 8

Phenotypes 32
Earliest

J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80(1):220-246
Latest

J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647

TSS for Tgm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20191	Chr2:129854256-129854270 (+)	-6 bp
Tssr20192	Chr2:129880370-129880396 (+)	26,114 bp
Tssr20193	Chr2:129882335-129882368 (+)	28,083 bp
Tssr20194	Chr2:129886451-129886460 (+)	32,187 bp
Tssr20195	Chr2:129886536-129886541 (+)	32,270 bp
Tssr20196	Chr2:129890464-129890489 (+)	36,208 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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