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Tgtp1 Gene Detail
Summary
  • Symbol
    Tgtp1
  • Name
    T cell specific GTPase 1
  • Synonyms
    Gtp2, Irgb6, Mg21, Tgtp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98734
    NCBI Gene: 21822
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:48876156-48883073 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 28.98 cM, cytoband B1.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98734
 protein coding gene Chr11:48876154-48884999 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018215
 protein coding gene Chr11:48108886-48115230 (-)
A/J MGP_AJ_G0018184
 protein coding gene Chr11:46256095-46265546 (-)
AKR/J MGP_AKRJ_G0018152
 protein coding gene Chr11:47705827-47712110 (-)
BALB/cJ MGP_BALBcJ_G0018153
 protein coding gene Chr11:46432440-46443641 (-)
C3H/HeJ MGP_C3HHeJ_G0017967
 protein coding gene Chr11:47712921-47730203 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0017529
 protein coding gene Chr11:47751163-47761622 (+)
CBA/J MGP_CBAJ_G0017939
 protein coding gene Chr11:51857701-51877076 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0018043
 protein coding gene Chr11:45636900-45645159 (-)
LP/J MGP_LPJ_G0018122
 protein coding gene Chr11:48429564-48439345 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018067
 protein coding gene Chr11:53366099-53388655 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018648
 protein coding gene Chr11:47819865-47829319 (-)
PWK/PhJ MGP_PWKPhJ_G0017310
 protein coding gene Chr11:46439865-46456653 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017103
 protein coding gene Chr11:47459644-47520525 (-)
WSB/EiJ MGP_WSBEiJ_G0017582
 protein coding gene Chr11:47457350-47466359 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    97
  • cDNA Data
    13
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21822 NCBI Gene Model | MGI Sequence Detail 6918 C57BL/6J ±  kb
transcript NM_011579 RefSeq | MGI Sequence Detail 2809 C57BL/6  
polypeptide Q62293 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15077
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 3
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:287230 Lee Y, et al., Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Life Sci Alliance. 2020 Jan;3(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory