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Timp3 Gene Detail
Summary
  • Symbol
    Timp3
  • Name
    tissue inhibitor of metalloproteinase 3
  • Synonyms
    Timp-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98754
    NCBI Gene: 21859
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:86136276-86185369 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 42.83 cM, cytoband C1-D1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1276 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98754
 protein coding gene Chr10:86136236-86185370 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017610
 protein coding gene Chr10:87258832-87309693 (+)
A/J MGP_AJ_G0017589
 protein coding gene Chr10:84346736-84395957 (+)
AKR/J MGP_AKRJ_G0017549
 protein coding gene Chr10:86705563-86755971 (+)
BALB/cJ MGP_BALBcJ_G0017552
 protein coding gene Chr10:84573048-84622254 (+)
C3H/HeJ MGP_C3HHeJ_G0017375
 protein coding gene Chr10:86733148-86783261 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018009
 protein coding gene Chr10:90202983-90252212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015693
 protein coding gene Chr10:80173002-80222768 (+)
CAST/EiJ MGP_CASTEiJ_G0016941
 protein coding gene Chr10:86606978-86655981 (+)
CBA/J MGP_CBAJ_G0017344
 protein coding gene Chr10:93934920-93984835 (+)
DBA/2J MGP_DBA2J_G0017451
 protein coding gene Chr10:83461385-83510615 (+)
FVB/NJ MGP_FVBNJ_G0017444
 protein coding gene Chr10:82725779-82774810 (+)
LP/J MGP_LPJ_G0017523
 protein coding gene Chr10:87925571-87976062 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017472
 protein coding gene Chr10:95540598-95607291 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018046
 protein coding gene Chr10:86585077-86635621 (+)
PWK/PhJ MGP_PWKPhJ_G0016722
 protein coding gene Chr10:83469282-83518777 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016511
 protein coding gene Chr10:85229246-85278413 (+)
WSB/EiJ MGP_WSBEiJ_G0016999
 protein coding gene Chr10:86548065-86610139 (+)



Homology
more
  • Human Ortholog
    TIMP3, TIMP metallopeptidase inhibitor 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMP3, TIMP metallopeptidase inhibitor 3
  • Synonyms
    HSMRK222, K222, K222TA2, SFD
  • Links
    NCBI Gene ID: 7078
    neXtProt AC: NX_P35625
    UniProt: P35625

  • Chr Location
    22q12.3; chr22:32801705-32863041 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Timp3 mouse models; 3 with human TIMP3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 5 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mice die prematurely with lethargy, ruffled hair, and a hunched posture, displaying impaired bronchiole branching, reduced alveologenesis and abnormal mammary gland involution. Knock-ins harboring a Ser156Cys missense mutation provide a mouse model for Sorsby fundus dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1169
  • Tissues
    189
  • cDNA Data
    317
  • Literature Summary
    63
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21859 NCBI Gene Model | MGI Sequence Detail 49094 C57BL/6J ±  kb
    transcript NM_011595 RefSeq | MGI Sequence Detail 4681 ZRU/MplStud  
    polypeptide P39876 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 339
      Genomic 3
      cDNA 320
      Primer pair 11
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15112, MGD-MRK-15114
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 63
      Diseases 3
      Gene Ontology 9
      Phenotypes 83
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory