Tnp1 MGI Mouse Gene Detail - MGI:98784

Symbol

Tnp1
Name

transition protein 1
Synonyms

Stp-1, Tp-1, TP1

Feature Type

protein coding gene
IDs

MGI:98784
NCBI Gene: 21958
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:73054233-73055058 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 36.94 cM
Mapping Data

17 experiments

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98784	protein coding gene	Chr1:73054233-73055068 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016138	protein coding gene	Chr1:73569951-73570786 (-)
A/J	MGP_AJ_G0016121	protein coding gene	Chr1:70984010-70984845 (-)
AKR/J	MGP_AKRJ_G0016078	protein coding gene	Chr1:72967599-72968434 (-)
BALB/cJ	MGP_BALBcJ_G0016076	protein coding gene	Chr1:71048696-71049531 (-)
C3H/HeJ	MGP_C3HHeJ_G0015907	protein coding gene	Chr1:73281241-73282076 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016529	protein coding gene	Chr1:76411197-76412032 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014250	protein coding gene	Chr1:66616410-66617244 (-)
CAST/EiJ	MGP_CASTEiJ_G0015491	protein coding gene	Chr1:72585670-72586505 (-)
CBA/J	MGP_CBAJ_G0015880	protein coding gene	Chr1:78918191-78919026 (-)
DBA/2J	MGP_DBA2J_G0015981	protein coding gene	Chr1:70317298-70318133 (-)
FVB/NJ	MGP_FVBNJ_G0015984	protein coding gene	Chr1:69497535-69498370 (-)
LP/J	MGP_LPJ_G0016053	protein coding gene	Chr1:74624828-74625663 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016004	protein coding gene	Chr1:82348011-82348846 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016576	protein coding gene	Chr1:72995399-72996234 (-)
PWK/PhJ	MGP_PWKPhJ_G0015278	protein coding gene	Chr1:69763371-69764206 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015056	protein coding gene	Chr1:72342878-72343717 (-)
WSB/EiJ	MGP_WSBEiJ_G0015553	protein coding gene	Chr1:72819867-72820702 (-)

Human Ortholog

TNP1, transition protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNP1, transition protein 1
Synonyms

TP1
Links

HGNC:11951

NCBI Gene ID: 7141

neXtProt AC: NX_P09430

UniProt: P09430
Chr Location

2q35; chr2:216859458-216860064 (-) GRCh38

MGI Vertebrate Homology

Tnp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TNP1
Gene Tree

Tnp1

less

Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tnp1
Incidental Mutations

APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

A portion of male homozygous null mice are infertile, exhibting defects in spermatogenesis and sperm motility.

less

All GO Annotations

35
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

1
cDNA Data

71
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS35611.1

Ensembl

ENSMUSG00000026182 (Evidence)
NCBI Gene

21958

			Length	Strain/Species	Flank
genomic	21958	NCBI Gene Model \| MGI Sequence Detail	826	C57BL/6J	± kb
transcript	NM_009407	RefSeq \| MGI Sequence Detail	431	Not Specified
polypeptide	P10856	UniProt \| EBI \| MGI Sequence Detail	55	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000016511 spermatid nuclear transition protein 1

(term hierarchy)
InterPro Domains

IPR001319 Nuclear transition protein 1

IPR020062 Nuclear transition protein 1, conserved site

less

All nucleic 78

Genomic 1

cDNA 72

Primer pair 3

Other 2

Microarray probesets 5

less

MGD-MRK-14634, MGD-MRK-15159, MGD-MRK-15173

Summaries

All 74

Developmental Gene Expression 10

Gene Ontology 12

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:306320 Ho UY, et al., WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Commun Biol. 2021 May 31;4(1):645

TSS for Tnp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12208	Chr1:73055043-73055060 (-)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24