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Tnp1 Gene Detail
Summary
  • Symbol
    Tnp1
  • Name
    transition protein 1
  • Synonyms
    Stp-1, Tp-1, TP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98784
    NCBI Gene: 21958
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:73054233-73055058 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98784
protein coding gene Chr1:73054233-73055068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016138
protein coding gene Chr1:73569951-73570786 (-)
A/J MGP_AJ_G0016121
protein coding gene Chr1:70984010-70984845 (-)
AKR/J MGP_AKRJ_G0016078
protein coding gene Chr1:72967599-72968434 (-)
BALB/cJ MGP_BALBcJ_G0016076
protein coding gene Chr1:71048696-71049531 (-)
C3H/HeJ MGP_C3HHeJ_G0015907
protein coding gene Chr1:73281241-73282076 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016529
protein coding gene Chr1:76411197-76412032 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014250
protein coding gene Chr1:66616410-66617244 (-)
CAST/EiJ MGP_CASTEiJ_G0015491
protein coding gene Chr1:72585670-72586505 (-)
CBA/J MGP_CBAJ_G0015880
protein coding gene Chr1:78918191-78919026 (-)
DBA/2J MGP_DBA2J_G0015981
protein coding gene Chr1:70317298-70318133 (-)
FVB/NJ MGP_FVBNJ_G0015984
protein coding gene Chr1:69497535-69498370 (-)
LP/J MGP_LPJ_G0016053
protein coding gene Chr1:74624828-74625663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016004
protein coding gene Chr1:82348011-82348846 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016576
protein coding gene Chr1:72995399-72996234 (-)
PWK/PhJ MGP_PWKPhJ_G0015278
protein coding gene Chr1:69763371-69764206 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015056
protein coding gene Chr1:72342878-72343717 (-)
WSB/EiJ MGP_WSBEiJ_G0015553
protein coding gene Chr1:72819867-72820702 (-)



Homology
more
  • Human Ortholog
    TNP1, transition protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNP1, transition protein 1
  • Synonyms
    TP1
  • Links
    NCBI Gene ID: 7141
    neXtProt AC: NX_P09430
    UniProt: P09430

  • Chr Location
    2q35; chr2:216859458-216860064 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A portion of male homozygous null mice are infertile, exhibting defects in spermatogenesis and sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21958 NCBI Gene Model | MGI Sequence Detail 826 C57BL/6J ±  kb
    transcript NM_009407 RefSeq | MGI Sequence Detail 431 Not Specified  
    polypeptide P10856 UniProt | EBI | MGI Sequence Detail 55 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 1
      cDNA 72
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14634, MGD-MRK-15159, MGD-MRK-15173
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:306320 Ho UY, et al., WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Commun Biol. 2021 May 31;4(1):645

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory