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Top2a Gene Detail
Summary
  • Symbol
    Top2a
  • Name
    topoisomerase (DNA) II alpha
  • Synonyms
    DNA Topoisomerase II alpha, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98790
    NCBI Gene: 21973
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98883769-98915015 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    884 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98790
 protein coding gene Chr11:98883769-98915037 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019080
 protein coding gene Chr11:101624747-101656902 (-)
A/J MGP_AJ_G0019048
 protein coding gene Chr11:97356001-97387904 (-)
AKR/J MGP_AKRJ_G0019018
 protein coding gene Chr11:100369237-100401929 (-)
BALB/cJ MGP_BALBcJ_G0019022
 protein coding gene Chr11:97849480-97880898 (-)
C3H/HeJ MGP_C3HHeJ_G0018835
 protein coding gene Chr11:100519458-100551475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019473
 protein coding gene Chr11:104756654-104791916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017105
 protein coding gene Chr11:94911623-94945443 (-)
CAST/EiJ MGP_CASTEiJ_G0018389
 protein coding gene Chr11:101508073-101539405 (-)
CBA/J MGP_CBAJ_G0018806
 protein coding gene Chr11:109106898-109141677 (-)
DBA/2J MGP_DBA2J_G0018914
 protein coding gene Chr11:96916902-96947911 (-)
FVB/NJ MGP_FVBNJ_G0018903
 protein coding gene Chr11:96432369-96464509 (-)
LP/J MGP_LPJ_G0018984
 protein coding gene Chr11:102082388-102118591 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018930
 protein coding gene Chr11:108787237-108821575 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019513
 protein coding gene Chr11:100729675-100761815 (-)
PWK/PhJ MGP_PWKPhJ_G0018160
 protein coding gene Chr11:97967741-97999581 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017949
 protein coding gene Chr11:100481381-100513845 (-)
WSB/EiJ MGP_WSBEiJ_G0018438
 protein coding gene Chr11:100687915-100728325 (-)



Homology
more
  • Human Ortholog
    TOP2A, DNA topoisomerase II alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOP2A, DNA topoisomerase II alpha
  • Synonyms
    TOP2, TOP2alpha, TOPIIA, TP2A
  • Links
    NCBI Gene ID: 7153
    neXtProt AC: NX_P11388
    UniProt: P11388

  • Chr Location
    17q21.2; chr17:40388525-40417896 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    104
  • cDNA Data
    595
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020914 Ensembl Gene Model | MGI Sequence Detail 31247 C57BL/6J ±  kb
    transcript ENSMUST00000068031 Ensembl | MGI Sequence Detail 5221 Not Applicable  
    polypeptide ENSMUSP00000068896 Ensembl | MGI Sequence Detail 1528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000016544 DNA topoisomerase 2-alpha
      (term hierarchy)
    • EC
      5.6.2.2
    • InterPro Domains
      IPR031660 C-terminal associated domain of TOPRIM
      IPR034157 DNA topoisomerase 2, TOPRIM domain
      IPR050634 DNA Topoisomerase II Enzyme
      IPR001154 DNA topoisomerase II, eukaryotic-type
      IPR001241 DNA topoisomerase, type IIA
      IPR013757 DNA topoisomerase, type IIA, alpha-helical domain superfamily
      IPR018522 DNA topoisomerase, type IIA, conserved site
      IPR002205 DNA topoisomerase, type IIA, domain A
      IPR013758 DNA topoisomerase, type IIA, domain A, alpha-beta
      IPR013760 DNA topoisomerase, type IIA-like domain superfamily
      IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
      IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
      IPR012542 DTHCT
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
      IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
      IPR006171 TOPRIM domain
    • GlyGen
      Q01320 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 607
      Genomic 1
      cDNA 604
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15166, MGD-MRK-15169
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 28
      Gene Ontology 22
      Phenotypes 20
    • Earliest
      J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
    • Latest
      J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory