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Top2b Gene Detail
Summary
  • Symbol
    Top2b
  • Name
    topoisomerase (DNA) II beta
  • Synonyms
    D230016L12Rik, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98791
    NCBI Gene: 21974
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:6038976-6104585 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1262 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98791
 protein coding gene Chr14:6034301-6104585 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021016
 protein coding gene Chr14:9000401-9069478 (+)
A/J MGP_AJ_G0020964
 protein coding gene Chr14:8734664-8799339 (+)
AKR/J MGP_AKRJ_G0020941
 protein coding gene Chr14:8960889-9029203 (+)
BALB/cJ MGP_BALBcJ_G0020967
 protein coding gene Chr14:8765027-8833871 (+)
C3H/HeJ MGP_C3HHeJ_G0020751
 protein coding gene Chr14:9068706-9135950 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021400
 protein coding gene Chr14:9257776-9327048 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018969
 protein coding gene Chr14:9346710-9411742 (+)
CAST/EiJ MGP_CASTEiJ_G0020274
 protein coding gene Chr14:8936531-9020711 (+)
CBA/J MGP_CBAJ_G0020717
 protein coding gene Chr14:9672557-9749255 (+)
DBA/2J MGP_DBA2J_G0020841
 protein coding gene Chr14:8664021-8731735 (+)
FVB/NJ MGP_FVBNJ_G0020823
 protein coding gene Chr14:8499199-8564886 (+)
LP/J MGP_LPJ_G0020916
 protein coding gene Chr14:9052530-9120824 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020849
 protein coding gene Chr14:9548120-9623690 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021433
 protein coding gene Chr14:8835925-8902935 (+)
PWK/PhJ MGP_PWKPhJ_G0020025
 protein coding gene Chr14:8689580-8756141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019846
 protein coding gene Chr14:9056463-9125774 (+)
WSB/EiJ MGP_WSBEiJ_G0020331
 protein coding gene Chr14:8881198-8951682 (+)



Homology
more
  • Human Ortholog
    TOP2B, DNA topoisomerase II beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOP2B, DNA topoisomerase II beta
  • Synonyms
    BILU, top2beta, TOPIIB
  • Links
    NCBI Gene ID: 7155
    neXtProt AC: NX_Q02880
    UniProt: Q02880

  • Chr Location
    3p24.2; chr3:25597905-25664909 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 4 alleles in 6 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure. Conditional KO in the retina results in postnatal retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    61
  • cDNA Data
    271
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21974 NCBI Gene Model | MGI Sequence Detail 65610 C57BL/6J ±  kb
    transcript NM_009409 RefSeq | MGI Sequence Detail 5661 C57BL/6  
    polypeptide Q64511 UniProt | EBI | MGI Sequence Detail 1612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016545 DNA topoisomerase 2-beta
      (term hierarchy)
    • EC
      5.6.2.2
    • InterPro Domains
      IPR031660 C-terminal associated domain of TOPRIM
      IPR034157 DNA topoisomerase 2, TOPRIM domain
      IPR050634 DNA Topoisomerase II Enzyme
      IPR001154 DNA topoisomerase II, eukaryotic-type
      IPR001241 DNA topoisomerase, type IIA
      IPR013757 DNA topoisomerase, type IIA, alpha-helical domain superfamily
      IPR018522 DNA topoisomerase, type IIA, conserved site
      IPR002205 DNA topoisomerase, type IIA, domain A
      IPR013758 DNA topoisomerase, type IIA, domain A, alpha-beta
      IPR013760 DNA topoisomerase, type IIA-like domain superfamily
      IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
      IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
      IPR012542 DTHCT
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
      IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
      IPR006171 TOPRIM domain
    • GlyGen
      Q64511 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 280
      cDNA 278
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15166, MGD-MRK-15170, MGI:2441960
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 17
      Gene Ontology 13
      Phenotypes 25
    • Earliest
      J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory