Tpm2 MGI Mouse Gene Detail - MGI:98810

Symbol

Tpm2
Name

tropomyosin 2, beta
Synonyms

Tpm-2, Trop-2

Feature Type

protein coding gene
IDs

MGI:98810
NCBI Gene: 22004
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr4:43514711-43523765 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.05 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98810	protein coding gene	Chr4:43513726-43523765 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028211	protein coding gene	Chr4:41635320-41644384 (-)
A/J	MGP_AJ_G0028167	protein coding gene	Chr4:40156592-40165655 (-)
AKR/J	MGP_AKRJ_G0028119	protein coding gene	Chr4:41068947-41078004 (-)
BALB/cJ	MGP_BALBcJ_G0028187	protein coding gene	Chr4:40244390-40254541 (-)
C3H/HeJ	MGP_C3HHeJ_G0027909	protein coding gene	Chr4:41694190-41704783 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028628	protein coding gene	Chr4:43197314-43206319 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025940	protein coding gene	Chr4:37604492-37612691 (-)
CAST/EiJ	MGP_CASTEiJ_G0027349	protein coding gene	Chr4:41199834-41210612 (-)
CBA/J	MGP_CBAJ_G0027875	protein coding gene	Chr4:44504041-44515847 (-)
DBA/2J	MGP_DBA2J_G0028024	protein coding gene	Chr4:40065176-40074330 (-)
FVB/NJ	MGP_FVBNJ_G0027991	protein coding gene	Chr4:39286887-39296359 (-)
LP/J	MGP_LPJ_G0028123	protein coding gene	Chr4:41687357-41696442 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028015	protein coding gene	Chr4:47768855-47778983 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028664	protein coding gene	Chr4:41265524-41275629 (-)
PWK/PhJ	MGP_PWKPhJ_G0027075	protein coding gene	Chr4:40109482-40118681 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026899	protein coding gene	Chr4:40808432-40817543 (-)
WSB/EiJ	MGP_WSBEiJ_G0027429	protein coding gene	Chr4:41167274-41177962 (-)

Human Ortholog

TPM2, tropomyosin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPM2, tropomyosin 2
Synonyms

AMCD1, CMYO23, CMYP23, DA1, DA2B, DA2B4, HEL-S-273, NEM4, TMSB
Links

HGNC:12011

NCBI Gene ID: 7169

neXtProt AC: NX_P07951

UniProt: P07951
Chr Location

9p13.3; chr9:35681992-35690056 (-) GRCh38

MGI Vertebrate Homology

Tpm2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPM2
Gene Tree

Tpm2

Diseases

2 with human TPM2 associations

				Human Disease	Mouse Models
				distal arthrogryposis type 1A IDs distal arthrogryposis type 1A DOID:0111597 MESH:C535378 OMIM:108120
				nemaline myopathy 4 IDs nemaline myopathy 4 DOID:0110932 MESH:C538351 OMIM:609285

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically and radiation induced

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Transgenic

1
Genomic Mutations

1 involving Tpm2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice for a null allele exhibit embryonic lethality. Heterozygotes develop cataracts and show impaired healing of lens wounds.

less

All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

83
cDNA Data

220
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tpm2

ZFIN tpm2

less

All Sequences

62
RefSeq

8
UniProt

7
CCDS

CCDS18100.1, CCDS71374.1

Ensembl

ENSMUSG00000028464 (Evidence)
NCBI Gene

22004

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028464	Ensembl Gene Model \| MGI Sequence Detail	9055	C57BL/6J	± kb
transcript	ENSMUST00000030184	Ensembl \| MGI Sequence Detail	2175	Not Applicable
polypeptide	ENSMUSP00000030184	Ensembl \| MGI Sequence Detail	284	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000016580 tropomyosin beta chain

(term hierarchy)
InterPro Domains

IPR014751 DNA repair protein XRCC4-like, C-terminal

IPR000533 Tropomyosin
GlyGen

P58774 1 site, 1 O-linked glycan (1 site)

less

All nucleic 229

Genomic 2

cDNA 224

Primer pair 2

Other 1

Microarray probesets 6

less

MGD-MRK-15203, MGD-MRK-15206, MGD-MRK-15241

Summaries

All 77

Developmental Gene Expression 18

Gene Ontology 7

Phenotypes 12
Earliest

J:9738 Takenaga K, et al., Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2. Mol Cell Biol. 1988 Dec;8(12):5561-5
Latest

J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992

TSS for Tpm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41443	Chr4:43523836-43523847 (-)	-77 bp
Tssr41442	Chr4:43523767-43523789 (-)	-13 bp
Tssr41441	Chr4:43523746-43523766 (-)	9 bp
Tssr41440	Chr4:43523674-43523699 (-)	78 bp
Tssr41439	Chr4:43523455-43523471 (-)	302 bp
Tssr1155	Chr4:43522849-43522903 (-)	889 bp
Tssr41438	Chr4:43522727-43522750 (-)	1,026 bp
Tssr41437	Chr4:43520045-43520059 (-)	3,713 bp
Tssr41436	Chr4:43519661-43519718 (-)	4,075 bp
Tssr41435	Chr4:43519255-43519299 (-)	4,488 bp
Tssr41434	Chr4:43518685-43518704 (-)	5,070 bp
Tssr41433	Chr4:43518459-43518473 (-)	5,299 bp
Tssr41432	Chr4:43518438-43518455 (-)	5,318 bp
Tssr41431	Chr4:43515787-43515801 (-)	7,971 bp
Tssr41430	Chr4:43515701-43515765 (-)	8,032 bp
Tssr41429	Chr4:43515302-43515321 (-)	8,453 bp
Tssr41428	Chr4:43515168-43515190 (-)	8,586 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24