Hsp90b1 MGI Mouse Gene Detail - MGI:98817 - heat shock protein 90, beta (Grp94), member 1

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Hsp90b1 Gene Detail

Symbol

Hsp90b1
Name

heat shock protein 90, beta (Grp94), member 1
Synonyms

90 kDa, endoplasmin, ERp99, gp96, GRP94, Targ2, Tra-1, Tra1, tumor rejection antigen (gp96) 1

Feature Type

protein coding gene
IDs

MGI:98817
NCBI Gene: 22027
Alliance

gene page
Transcription Start Sites

13 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr10:86526705-86541308 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 43.05 cM
Mapping Data

20 experiments

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SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_98817	protein coding gene	Chr10:86526073-86541373 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017612	protein coding gene	Chr10:87668288-87685297 (-)
A/J	MGP_AJ_G0017591	protein coding gene	Chr10:84771340-84787578 (-)
AKR/J	MGP_AKRJ_G0017550	protein coding gene	Chr10:87150475-87167994 (-)
BALB/cJ	MGP_BALBcJ_G0017554	protein coding gene	Chr10:85033710-85049439 (-)
C3H/HeJ	MGP_C3HHeJ_G0017377	protein coding gene	Chr10:87156302-87171275 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018011	protein coding gene	Chr10:90638209-90655281 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015694	protein coding gene	Chr10:80566642-80581741 (-)
CAST/EiJ	MGP_CASTEiJ_G0016943	protein coding gene	Chr10:87040547-87055679 (-)
CBA/J	MGP_CBAJ_G0017346	protein coding gene	Chr10:94404447-94419738 (-)
DBA/2J	MGP_DBA2J_G0017452	protein coding gene	Chr10:83874451-83889649 (-)
FVB/NJ	MGP_FVBNJ_G0017445	protein coding gene	Chr10:83139638-83154489 (-)
LP/J	MGP_LPJ_G0017526	protein coding gene	Chr10:88360827-88377353 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017475	protein coding gene	Chr10:95975313-95991604 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018048	protein coding gene	Chr10:87001174-87016940 (-)
PWK/PhJ	MGP_PWKPhJ_G0016724	protein coding gene	Chr10:83880446-83895802 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016512	protein coding gene	Chr10:85722867-85739771 (-)
WSB/EiJ	MGP_WSBEiJ_G0017002	protein coding gene	Chr10:86956196-86973146 (-)

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Human Ortholog

HSP90B1, heat shock protein 90 beta family member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSP90B1, heat shock protein 90 beta family member 1
Synonyms

ECGP, GP96, GRP94, HEL35, HEL-S-125m, TRA1
Links

HGNC:12028

NCBI Gene ID: 7184

neXtProt AC: NX_P14625

UniProt: P14625
Chr Location

12q23.3; chr12:103930107-103953931 (+) GRCh38

Human Ortholog

HSP90B2P, heat shock protein 90 beta family member 2, pseudogene
Synonyms

GRP94b, GRP94P1, HSP, HSPCP2, TRA1P1, TRAP1
Links

HGNC:12099

NCBI Gene ID: 7190

UniProt: Q58FF3
Chr Location

15q26.3; chr15:99257525-99260276 (+) GRCh38

MGI Vertebrate Homology

Hsp90b1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSP90B1, HSP90B2P
Protein SuperFamily

Hsp90
Gene Tree

Hsp90b1

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Diseases

1 with Hsp90b1 mouse models

Human Disease

Mouse Models

Mouse gene associated with disease

male infertility due to globozoospermia

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

34 phenotypes from 4 alleles in 5 genetic backgrounds
1 images
47 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

16
Targeted

8
Genomic Mutations

1 involving Hsp90b1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display embryonic lethality before somite formation with failure of primitive streak formation, absence of the chorion and amnion, and failure of mesoderm formation.

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All GO Annotations

45
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

64
cDNA Data

941
Literature Summary

31

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HSP90B1

Xenbase hsp90b1

ZFIN hsp90b1

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All Sequences

86
RefSeq

2
UniProt

9
CCDS

CCDS36019.1

Ensembl

ENSMUSG00000020048 (Evidence)
NCBI Gene

22027

Representative Sequences				Length	Strain/Species	Flank
	genomic	22027	NCBI Gene Model \| MGI Sequence Detail	14604	C57BL/6J	± kb
	transcript	NM_011631	RefSeq \| MGI Sequence Detail	2759	Not Specified
	polypeptide	P08113	UniProt \| EBI \| MGI Sequence Detail	802	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008801 endoplasmin

(term hierarchy)
InterPro Domains

IPR019805 Heat shock protein Hsp90, conserved site

IPR001404 Heat shock protein Hsp90 family

IPR020575 Heat shock protein Hsp90, N-terminal

IPR003594 Histidine kinase/HSP90-like ATPase

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR037196 HSP90, C-terminal domain

IPR020568 Ribosomal protein uS5 domain 2-type superfamily
GlyGen

P08113 8 sites, 19 N-linked glycans (6 sites), 1 O-linked glycan (2 sites)

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All nucleic 952

Genomic 3

cDNA 943

Primer pair 3

Other 3

Microarray probesets 4

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MGD-MRK-15216, MGD-MRK-15219, MGI:1100861

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Summaries

All 167

Developmental Gene Expression 31

Diseases 1

Gene Ontology 18

Phenotypes 47
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353425 Xu Y, et al., Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes. Nat Commun. 2024 Feb 6;15(1):1106

TSS for Hsp90b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98789	Chr10:86541251-86541262 (-)	51 bp
Tssr98788	Chr10:86540191-86540217 (-)	1,104 bp
Tssr98787	Chr10:86539424-86539471 (-)	1,860 bp
Tssr98786	Chr10:86538807-86538888 (-)	2,460 bp
Tssr98785	Chr10:86538094-86538105 (-)	3,208 bp
Tssr98784	Chr10:86537841-86537859 (-)	3,458 bp
Tssr98783	Chr10:86537816-86537837 (-)	3,481 bp
Tssr98782	Chr10:86537690-86537726 (-)	3,600 bp
Tssr98781	Chr10:86537666-86537682 (-)	3,634 bp
Tssr98780	Chr10:86537626-86537647 (-)	3,671 bp
Tssr98779	Chr10:86531577-86531607 (-)	9,716 bp
Tssr98778	Chr10:86531380-86531409 (-)	9,913 bp
Tssr98771	Chr10:86527562-86527619 (-)	13,717 bp

Hsp90b1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Igfbp3q2	Chr10, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.
Insq4	Chr10, 54.72 cM	Chr10:103909085-103909229	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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