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Trhr Gene Detail
Summary
  • Symbol
    Trhr
  • Name
    thyrotropin releasing hormone receptor
  • Synonyms
    TRH-R1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98824
    NCBI Gene: 22045
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr15:44059531-44099308 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.82 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1130 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98824
 protein coding gene Chr15:44059314-44099308 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021828
 protein coding gene Chr15:42789751-42834247 (+)
A/J MGP_AJ_G0021788
 protein coding gene Chr15:41167270-41209187 (+)
AKR/J MGP_AKRJ_G0021769
 protein coding gene Chr15:42385478-42424971 (+)
BALB/cJ MGP_BALBcJ_G0021795
 protein coding gene Chr15:41251596-41294926 (+)
C3H/HeJ MGP_C3HHeJ_G0021569
 protein coding gene Chr15:42305447-42345953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022234
 protein coding gene Chr15:44463138-44508497 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019771
 protein coding gene Chr15:38712417-38762950 (+)
CAST/EiJ MGP_CASTEiJ_G0021086
 protein coding gene Chr15:42827780-42873198 (+)
CBA/J MGP_CBAJ_G0021538
 protein coding gene Chr15:45997845-46048685 (+)
DBA/2J MGP_DBA2J_G0021662
 protein coding gene Chr15:40967106-41013723 (+)
FVB/NJ MGP_FVBNJ_G0021640
 protein coding gene Chr15:40280085-40318818 (+)
LP/J MGP_LPJ_G0021732
 protein coding gene Chr15:42563514-42604235 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021664
 protein coding gene Chr15:49373511-49415793 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022257
 protein coding gene Chr15:42576819-42617969 (+)
PWK/PhJ MGP_PWKPhJ_G0020831
 protein coding gene Chr15:41027549-41066563 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020668
 protein coding gene Chr15:42267993-42305990 (+)
WSB/EiJ MGP_WSBEiJ_G0021141
 protein coding gene Chr15:42467683-42514688 (+)



Homology
more
  • Human Ortholog
    TRHR, thyrotropin releasing hormone receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRHR, thyrotropin releasing hormone receptor
  • Synonyms
    CHNG7, TRH-R
  • Links
    NCBI Gene ID: 7201
    neXtProt AC: NX_P34981
    UniProt: P34981

  • Chr Location
    8q23.1; chr8:109086585-109121565 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trhr mouse models; 2 with human TRHR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display decreased thyroxine, triiodothyronine, and prolactin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    102
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038760 Ensembl Gene Model | MGI Sequence Detail 39778 C57BL/6J ±  kb
    transcript ENSMUST00000110289 Ensembl | MGI Sequence Detail 1745 Not Applicable  
    polypeptide ENSMUSP00000105918 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001557 thyrotropin-releasing hormone receptor type 1
      (term hierarchy)
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR002120 Thyrotropin-releasing hormone receptor
    • GlyGen
      P21761 3 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 13
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15227
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326429 Kwon JT, et al., An amygdala circuit that suppresses social engagement. Nature. 2021 May;593(7857):114-118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory