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Prss1 Gene Detail
Summary
  • Symbol
    Prss1
  • Name
    serine protease 1 (trypsin 1)
  • Synonyms
    PRSS1, Try-1, Try1, Trygn16
  • Feature Type
    protein coding gene
  • IDs
    MGI:98839
    NCBI Gene: 114228
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41435866-41440720 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.60 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    11
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98839
 protein coding gene Chr6:41435864-41440720 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030626
 protein coding gene Chr6:39902791-39904543 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0030323
 protein coding gene Chr6:39424240-39499587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031065
 protein coding gene Chr6:40953984-40975892 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029727
 protein coding gene Chr6:39260752-39262096 (-)
CBA/J MGP_CBAJ_G0030300
 protein coding gene Chr6:42568502-42583228 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0030397
 protein coding gene Chr6:37710532-37716073 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031095
 protein coding gene Chr6:39344780-39354511 (+)
PWK/PhJ MGP_PWKPhJ_G0029440
 protein coding gene Chr6:37577739-37583359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029277
 protein coding gene Chr6:39048046-39052013 (+)
WSB/EiJ MGP_WSBEiJ_G0029803
 protein coding gene Chr6:39250181-39253165 (-)



Homology
more
  • Human Ortholog
    PRSS1, serine protease 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS1, serine protease 1
  • Synonyms
    TRP1, TRY1, TRY4, TRYP1
  • Links
    NCBI Gene ID: 5644
    neXtProt AC: NX_P07477
    UniProt: P07477

  • Chr Location
    7q34; chr7:142749468-142753072 (+)  GRCh38
  • Human Ortholog
    PRSS2, serine protease 2
  • Synonyms
    TRY2, TRY8, TRYP2
  • Links
    NCBI Gene ID: 5645
    neXtProt AC: NX_P07478
    UniProt: P07478

  • Chr Location
    7q34; chr7:142760398-142774564 (+)  GRCh38
  • Human Ortholog
    PRSS3P2, PRSS3 pseudogene 2
  • Synonyms
    T6, TRY6
  • Links
    NCBI Gene ID: 154754
    UniProt: Q8NHM4

  • Chr Location
    7q34
Human Diseases
more
  • Diseases
    1 with human PRSS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    5
  • cDNA Data
    1
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062751 Ensembl Gene Model | MGI Sequence Detail 4855 C57BL/6J ±  kb
    transcript ENSMUST00000031910 Ensembl | MGI Sequence Detail 805 Not Applicable  
    polypeptide ENSMUSP00000031910 Ensembl | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      3.4.21.4
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR050127 Serine Proteases (Peptidase S1 Family)
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    • GlyGen
      Q9Z1R9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15253, MGD-MRK-15254, MGI:2148749
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:7529 Honey NK, et al., Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul;10(4):377-83
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory