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Upk2 Gene Detail
Summary
  • Symbol
    Upk2
  • Name
    uroplakin 2
  • Synonyms
    UPII, uroplakin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:98913
    NCBI Gene: 22269
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44364012-44366064 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98913
 protein coding gene Chr9:44364012-44366273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034711
 protein coding gene Chr9:42944824-42946891 (-)
A/J MGP_AJ_G0034692
 protein coding gene Chr9:41744341-41746392 (-)
AKR/J MGP_AKRJ_G0034618
 protein coding gene Chr9:42608851-42610902 (-)
BALB/cJ MGP_BALBcJ_G0034683
 protein coding gene Chr9:41490331-41492382 (-)
C3H/HeJ MGP_C3HHeJ_G0034394
 protein coding gene Chr9:43067913-43069964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035204
 protein coding gene Chr9:44216756-44218807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032119
 protein coding gene Chr9:41330396-41332452 (-)
CAST/EiJ MGP_CASTEiJ_G0033716
 protein coding gene Chr9:42914936-42916970 (-)
CBA/J MGP_CBAJ_G0034366
 protein coding gene Chr9:45830767-45832818 (-)
DBA/2J MGP_DBA2J_G0034525
 protein coding gene Chr9:41646507-41648558 (-)
FVB/NJ MGP_FVBNJ_G0034466
 protein coding gene Chr9:40899591-40901642 (-)
LP/J MGP_LPJ_G0034606
 protein coding gene Chr9:43247497-43249564 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034510
 protein coding gene Chr9:47666698-47668749 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035225
 protein coding gene Chr9:42511616-42513667 (-)
PWK/PhJ MGP_PWKPhJ_G0033422
 protein coding gene Chr9:41524503-41526570 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033256
 protein coding gene Chr9:42830938-42833004 (-)
WSB/EiJ MGP_WSBEiJ_G0033829
 protein coding gene Chr9:42549621-42551672 (-)



Homology
more
  • Human Ortholog
    UPK2, uroplakin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK2, uroplakin 2
  • Synonyms
    UP2, UPII
  • Links
    NCBI Gene ID: 7379
    neXtProt AC: NX_O00526
    UniProt: O00526

  • Chr Location
    11q23.3; chr11:118925164-118958559 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    4 images
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal urothelium that lacks umbrella cells, hydronephrosis, partial or complete ureter obstruction, increased vesicoureteral reflux, increased blood urea nitrogen levels, polyuria, and partial postnatal lethality with growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    24
  • cDNA Data
    6
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22269 NCBI Gene Model | MGI Sequence Detail 2053 C57BL/6J ±  kb
    transcript NM_009476 RefSeq | MGI Sequence Detail 890 ZRU/MplStud  
    polypeptide P38575 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 7
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15368, MGI:2143308
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 2
    • Earliest
      J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
    • Latest
      J:327332 Kurz J, et al., GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter. Development. 2022 Aug 1;149(15):dev200522
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory