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Vcam1 Gene Detail
Summary
  • Symbol
    Vcam1
  • Name
    vascular cell adhesion molecule 1
  • Synonyms
    CD106, Vcam-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98926
    NCBI Gene: 22329
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:115903669-115923337 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.17 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    607 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98926
 protein coding gene Chr3:115903598-115923337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027807
 protein coding gene Chr3:117989101-118009678 (-)
A/J MGP_AJ_G0027765
 protein coding gene Chr3:114123397-114143037 (-)
AKR/J MGP_AKRJ_G0027731
 protein coding gene Chr3:117005748-117025385 (-)
BALB/cJ MGP_BALBcJ_G0027777
 protein coding gene Chr3:113971734-113991490 (-)
C3H/HeJ MGP_C3HHeJ_G0027508
 protein coding gene Chr3:117372154-117392170 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028223
 protein coding gene Chr3:122321392-122342290 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025562
 protein coding gene Chr3:109817917-109837522 (-)
CAST/EiJ MGP_CASTEiJ_G0026964
 protein coding gene Chr3:116649352-116669127 (-)
CBA/J MGP_CBAJ_G0027483
 protein coding gene Chr3:126490003-126510822 (-)
DBA/2J MGP_DBA2J_G0027624
 protein coding gene Chr3:113365834-113385282 (-)
FVB/NJ MGP_FVBNJ_G0027592
 protein coding gene Chr3:111004924-111024712 (-)
LP/J MGP_LPJ_G0027734
 protein coding gene Chr3:119533569-119553141 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027622
 protein coding gene Chr3:133863122-133883130 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028279
 protein coding gene Chr3:116559983-116580549 (-)
PWK/PhJ MGP_PWKPhJ_G0026690
 protein coding gene Chr3:113002086-113022241 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026512
 protein coding gene Chr3:114562116-114582853 (-)
WSB/EiJ MGP_WSBEiJ_G0027044
 protein coding gene Chr3:117235355-117254823 (-)



Homology
more
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VCAM1, vascular cell adhesion molecule 1
  • Synonyms
    CD106, INCAM-100
  • Links
    NCBI Gene ID: 7412
    neXtProt AC: NX_P19320
    UniProt: P19320

  • Chr Location
    1p21.2; chr1:100719742-100739045 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VCAM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 7 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mutants die by embryonic day 12.5 due to defective placenta and failure of chorion/allantois fusion, and heart developmental anomalies. Survivors are generally normal, but have high numbers of circulating blood mononuclear leukocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    159
  • cDNA Data
    29
  • Literature Summary
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22329 NCBI Gene Model | MGI Sequence Detail 19669 C57BL/6J ±  kb
    transcript NM_011693 RefSeq | MGI Sequence Detail 3398 Not Specified  
    polypeptide P29533 UniProt | EBI | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000001970 vascular cell adhesion protein 1
      (term hierarchy)
    • InterPro Domains
      IPR008424 Immunoglobulin C2-set
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule
      IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
      IPR003989 Vascular cell adhesion molecule-1
    • GlyGen
      P29533 5 sites, 10 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 13
      cDNA 30
      Primer pair 10
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-15384, MGD-MRK-15385
    References
    more
    • Summaries
      All 287
      Developmental Gene Expression 120
      Diseases 1
      Gene Ontology 14
      Phenotypes 40
    • Earliest
      J:18518 Osborn L, et al., Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 1989 Dec 22;59(6):1203-11
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory