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Vpreb1a Gene Detail
Summary
  • Symbol
    Vpreb1a
  • Name
    V-set pre-B cell surrogate light chain 1A
  • Synonyms
    CD179a, Vpreb-1, Vpreb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98936
    NCBI Gene: 22362
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr16:16686265-16687119 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.46 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98936
 protein coding gene Chr16:16686265-16688707 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022563
 protein coding gene Chr16:13960062-13964912 (-)
A/J MGP_AJ_G0022524
 protein coding gene Chr16:13278134-13278986 (-)
AKR/J MGP_AKRJ_G0022500
 protein coding gene Chr16:13821285-13821986 (-)
BALB/cJ MGP_BALBcJ_G0022565
 protein coding gene Chr16:14572139-14572991 (+)
C3H/HeJ MGP_C3HHeJ_G0022331
 protein coding gene Chr16:15145053-15145365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022977
 protein coding gene Chr16:14181637-14184078 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020498
 protein coding gene Chr16:13362224-13363076 (-)
CAST/EiJ MGP_CASTEiJ_G0021822
 protein coding gene Chr16:13856176-13856925 (-)
CBA/J MGP_CBAJ_G0022265
 protein coding gene Chr16:14843141-14844197 (-)
DBA/2J MGP_DBA2J_G0022433
 protein coding gene Chr16:14327844-14328383 (+)
FVB/NJ MGP_FVBNJ_G0022371
 protein coding gene Chr16:13239898-13242282 (-)
LP/J MGP_LPJ_G0022500
 protein coding gene Chr16:14960098-14962047 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022430
 protein coding gene Chr16:15773602-15774319 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021564
 protein coding gene Chr16:13455746-13456591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021393
 protein coding gene Chr16:13734242-13735093 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    VPREB1, V-set pre-B cell surrogate light chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPREB1, V-set pre-B cell surrogate light chain 1
  • Synonyms
    CD179a, IGI, IGVPB, VPREB
  • Links
    NCBI Gene ID: 7441
    neXtProt AC: NX_P12018
    UniProt: P12018

  • Chr Location
    22q11.22; chr22:22244780-22245515 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have fewer cells with functional pre-B cell receptors. Double knockouts homozygous for null mutations at Vpreb1 and Vpreb2 show impaired B-cell development. Fewer B-cells are found in bone marrow, spleen and peritoneum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    8
  • cDNA Data
    5
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22362 NCBI Gene Model | MGI Sequence Detail 855 C57BL/6J ±  kb
transcript NM_016982 RefSeq | MGI Sequence Detail 772 ZRU/MplStud  
polypeptide P13372 UniProt | EBI | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR050150 Immunoglobulin Variable Light Chain
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
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  • All nucleic 21
    Genomic 12
    cDNA 6
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15409, MGD-MRK-15412, MGI:7387116
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:8871 Kudo A, et al., A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 1987 Aug;6(8):2267-72
  • Latest
    J:345215 Aranburu A, et al., Clonal relationships of memory B cell subsets in autoimmune mice. Front Immunol. 2023;14:1129234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory