Vtn MGI Mouse Gene Detail - MGI:98940

Symbol

Vtn
Name

vitronectin
Synonyms

Vn

Feature Type

protein coding gene
IDs

MGI:98940
NCBI Gene: 22370
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr11:78389946-78393151 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

6 experiments

SNPs within 2kb

159 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98940	protein coding gene	Chr11:78389917-78393151 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018782	protein coding gene	Chr11:79517549-79520782 (+)
A/J	MGP_AJ_G0018748	protein coding gene	Chr11:76470179-76473412 (+)
AKR/J	MGP_AKRJ_G0018718	protein coding gene	Chr11:78773841-78777074 (+)
BALB/cJ	MGP_BALBcJ_G0018722	protein coding gene	Chr11:76873284-76876517 (+)
C3H/HeJ	MGP_C3HHeJ_G0018535	protein coding gene	Chr11:78820787-78824020 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019173	protein coding gene	Chr11:81986375-81989608 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016808	protein coding gene	Chr11:73440352-73443580 (+)
CAST/EiJ	MGP_CASTEiJ_G0018089	protein coding gene	Chr11:79276325-79280759 (+)
CBA/J	MGP_CBAJ_G0018506	protein coding gene	Chr11:85596383-85599616 (+)
DBA/2J	MGP_DBA2J_G0018614	protein coding gene	Chr11:76044868-76048101 (+)
FVB/NJ	MGP_FVBNJ_G0018604	protein coding gene	Chr11:75635110-75638300 (+)
LP/J	MGP_LPJ_G0018685	protein coding gene	Chr11:80032463-80035696 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018630	protein coding gene	Chr11:85957558-85960791 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019213	protein coding gene	Chr11:79021886-79025119 (+)
PWK/PhJ	MGP_PWKPhJ_G0017860	protein coding gene	Chr11:76841330-76844525 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017651	protein coding gene	Chr11:78638380-78641556 (+)
WSB/EiJ	MGP_WSBEiJ_G0018142	protein coding gene	Chr11:78850600-78853791 (+)

Human Ortholog

VTN, vitronectin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VTN, vitronectin
Synonyms

V75, VN, VNT
Links

HGNC:12724

NCBI Gene ID: 7448

neXtProt AC: NX_P04004

UniProt: P04004
Chr Location

17q11.2; chr17:28367284-28373091 (-) GRCh38

MGI Vertebrate Homology

Vtn stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: VTN
Gene Tree

Vtn

Diseases

3 with human VTN associations

				Human Disease	Mouse Models
				Churg-Strauss syndrome IDs Churg-Strauss syndrome DOID:3049 ICD10CM:M30.1 MESH:D015267 NCI:C34481 UMLS_CUI:C0008728
				granulomatosis with polyangiitis IDs granulomatosis with polyangiitis DOID:12132 ICD10CM:M31.3 ICD9CM:446.4 MESH:D014890 NCI:C3444 OMIM:608710 UMLS_CUI:C3495801
				thrombosis IDs thrombosis DOID:0060903 MESH:D013927

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

3 involving Vtn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Homozygotes and heterozygotes for a targeted null mutation appear to develop, mature, and reproduce normally.

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All GO Annotations

69
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1127
Tissues

226
cDNA Data

424
Literature Summary

28

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vtn

ZFIN vtnb

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS25106.1

Ensembl

ENSMUSG00000017344 (Evidence)
NCBI Gene

22370

			Length	Strain/Species	Flank
genomic	22370	NCBI Gene Model \| MGI Sequence Detail	3206	C57BL/6J	± kb
transcript	NM_011707	RefSeq \| MGI Sequence Detail	1763	ZRU/MplStud
polypeptide	P29788	UniProt \| EBI \| MGI Sequence Detail	478	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017360 vitronectin

(term hierarchy)
InterPro Domains

IPR051298 Heme transport and cell adhesion protein

IPR018486 Hemopexin, conserved site

IPR000585 Hemopexin-like domain

IPR036375 Hemopexin-like domain superfamily

IPR018487 Hemopexin-like repeats

IPR001212 Somatomedin B domain

IPR020436 Somatomedin B domain, chordata

IPR036024 Somatomedin B-like domain superfamily
GlyGen

P29788 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 440

Genomic 7

cDNA 425

Primer pair 8

Microarray probesets 4

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MGD-MRK-15418, MGI:2144094

Summaries

All 127

Developmental Gene Expression 28

Gene Ontology 14

Phenotypes 41
Earliest

J:23999 Kolb WP, et al., The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex. J Exp Med. 1975 Apr 1;141(4):724-35
Latest

J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)

TSS for Vtn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103300	Chr11:78389835-78389848 (+)	-104 bp
Tssr103301	Chr11:78389862-78389867 (+)	-81 bp
Tssr103302	Chr11:78389869-78389891 (+)	-66 bp
Tssr103303	Chr11:78389892-78389906 (+)	-47 bp
Tssr103304	Chr11:78389913-78389949 (+)	-15 bp
Tssr103305	Chr11:78389953-78389957 (+)	9 bp
Tssr103306	Chr11:78390072-78390098 (+)	139 bp
Tssr103307	Chr11:78390316-78390416 (+)	420 bp
Tssr103308	Chr11:78390529-78390545 (+)	591 bp
Tssr103309	Chr11:78390585-78390604 (+)	649 bp
Tssr103310	Chr11:78390614-78390631 (+)	677 bp
Tssr103311	Chr11:78390658-78390668 (+)	717 bp
Tssr103312	Chr11:78390669-78390682 (+)	730 bp
Tssr103313	Chr11:78390694-78390707 (+)	755 bp
Tssr103314	Chr11:78390942-78390961 (+)	1,006 bp
Tssr103315	Chr11:78391297-78391311 (+)	1,358 bp
Tssr103316	Chr11:78391905-78391917 (+)	1,965 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24