Wap MGI Mouse Gene Detail - MGI:98943

Symbol

Wap
Name

whey acidic protein

Feature Type

protein coding gene
IDs

MGI:98943
NCBI Gene: 22373
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:6585482-6588637 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 4.61 cM
Mapping Data

2 experiments

SNPs within 2kb

211 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98943	protein coding gene	Chr11:6585482-6588654 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018029	protein coding gene	Chr11:3785417-3788409 (-)
A/J	MGP_AJ_G0018002	protein coding gene	Chr11:3614490-3617810 (-)
AKR/J	MGP_AKRJ_G0017966	protein coding gene	Chr11:3790338-3794376 (-)
BALB/cJ	MGP_BALBcJ_G0017970	protein coding gene	Chr11:3623188-3626575 (-)
C3H/HeJ	MGP_C3HHeJ_G0017783	protein coding gene	Chr11:3680316-3683340 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018422	protein coding gene	Chr11:3877621-3880580 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016080	protein coding gene	Chr11:3501037-3503542 (-)
CAST/EiJ	MGP_CASTEiJ_G0017345	protein coding gene	Chr11:3671275-3674134 (-)
CBA/J	MGP_CBAJ_G0017758	protein coding gene	Chr11:4310241-4313268 (-)
DBA/2J	MGP_DBA2J_G0017868	protein coding gene	Chr11:3523720-3526908 (-)
FVB/NJ	MGP_FVBNJ_G0017860	protein coding gene	Chr11:3551215-3555195 (-)
LP/J	MGP_LPJ_G0017939	protein coding gene	Chr11:3847131-3849957 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017886	protein coding gene	Chr11:3859131-3862188 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018462	protein coding gene	Chr11:3821633-3824625 (-)
PWK/PhJ	MGP_PWKPhJ_G0017125	protein coding gene	Chr11:3562551-3565706 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016922	protein coding gene	Chr11:3767921-3770892 (-)
WSB/EiJ	MGP_WSBEiJ_G0017399	protein coding gene	Chr11:3650316-3654162 (-)

less

MGI Vertebrate Homology

Wap stringent orthology
1 mouse;1 rat
Gene Tree

Wap

less

Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

less

Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
2 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change inWAP protein in YBR versus other strains.

less

All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

45
cDNA Data

237
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS24424.1

Ensembl

ENSMUSG00000000381 (Evidence)
NCBI Gene

22373

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000381	Ensembl Gene Model \| MGI Sequence Detail	3156	C57BL/6J	± kb
transcript	ENSMUST00000102910	Ensembl \| MGI Sequence Detail	551	Not Applicable
polypeptide	ENSMUSP00000099974	Ensembl \| MGI Sequence Detail	134	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000017467 whey acidic protein

(term hierarchy)
InterPro Domains

IPR036645 Elafin-like superfamily

IPR050514 WAP four-disulfide core domain

IPR008197 WAP-type 'four-disulfide core' domain

less

All nucleic 246

Genomic 5

cDNA 237

Primer pair 1

Other 3

Microarray probesets 3

less

MGD-MRK-15427

Summaries

All 61

Developmental Gene Expression 6

Diseases 3

Gene Ontology 3

Phenotypes 18
Earliest

J:6634 Piletz JE, et al., Biochemical characterization of a novel whey protein from murine milk. J Biol Chem. 1981 Nov 25;256(22):11509-16
Latest

J:269948 Stratikopoulos EE, et al., Mouse ER+/PIK3CA(H1047R) breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents. Oncogene. 2019 Jan;38(1):47-59

TSS for Wap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106759	Chr11:6588791-6588797 (-)	-157 bp
Tssr106758	Chr11:6588640-6588655 (-)	-11 bp
Tssr106757	Chr11:6588571-6588585 (-)	59 bp
Tssr106756	Chr11:6587273-6587302 (-)	1,349 bp
Tssr106755	Chr11:6587245-6587260 (-)	1,384 bp
Tssr106754	Chr11:6585578-6585583 (-)	3,056 bp
Tssr106753	Chr11:6585568-6585572 (-)	3,067 bp
Tssr106752	Chr11:6585545-6585555 (-)	3,087 bp
Tssr106751	Chr11:6585536-6585541 (-)	3,098 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24