Wld Gene Detail

Summary

• Symbol
  Wld
• Name
  wallerian degeneration
• Synonyms
  Wlds

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:98952
  NCBI Gene: 22406
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr4:149260776-149632709 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, Syntenic
• Mapping Data
  6 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  12 phenotypes from multigenic genotypes
  127 phenotype references
  

• All Mutations and Alleles
  14
• Spontaneous
  1
• Transgenic
  13
• Find Mice (IMSR)
  2 strains or lines available

Wallerian degeneration is important in axon regeneration initiation. C57BL/Ola mice carry a mutation for slow Wallerian degeneration resulting in slower regeneration of sciatic sensory axons when they are cut or crushed. Age affects expression and older C57BL/Ola show faster Wallerian degeneration.

Sequences &
Gene Models

• All Sequences
  3

• NCBI Gene
  22406

Representative Sequences			Length	Strain/Species
genomic	AF260927	GenBank | ENA | DDBJ | MGI Sequence Detail	90497	129 and C57BL/6J

Molecular
Reagents

• All nucleic 74

  Genomic 74

Other
Accession IDs

MGD-MRK-15436

References

• Summaries
  All 140

  Phenotypes 127
• Earliest
  J:19951 Lunn ER, et al., Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci. 1989 Jan;1(1):27-33
• Latest
  J:327261 Buscham TJ, et al., Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5. Elife. 2022 Mar 11;11:e75523