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Wnt2 Gene Detail
Summary
  • Symbol
    Wnt2
  • Name
    wingless-type MMTV integration site family, member 2
  • Synonyms
    2610510E18Rik, Int1l1, Irp, m-irp, Mirp, Wnt-2, Wnt2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98954
    NCBI Gene: 22413
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:17988939-18030584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 8.08 cM, cytoband A2-A3.1
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1168 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98954
 protein coding gene Chr6:17988939-18032771 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030473
 protein coding gene Chr6:15268112-15311830 (-)
A/J MGP_AJ_G0030446
 protein coding gene Chr6:14644473-14687337 (-)
AKR/J MGP_AKRJ_G0030373
 protein coding gene Chr6:15150537-15195808 (-)
BALB/cJ MGP_BALBcJ_G0030455
 protein coding gene Chr6:14739847-14781529 (-)
C3H/HeJ MGP_C3HHeJ_G0030169
 protein coding gene Chr6:15025888-15072066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030910
 protein coding gene Chr6:15745194-15790579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028121
 protein coding gene Chr6:13590709-13632524 (-)
CAST/EiJ MGP_CASTEiJ_G0029571
 protein coding gene Chr6:14935525-14976902 (-)
CBA/J MGP_CBAJ_G0030147
 protein coding gene Chr6:16257103-16298530 (-)
DBA/2J MGP_DBA2J_G0030291
 protein coding gene Chr6:14577522-14619066 (-)
FVB/NJ MGP_FVBNJ_G0030245
 protein coding gene Chr6:14405722-14448534 (-)
LP/J MGP_LPJ_G0030378
 protein coding gene Chr6:15368780-15421427 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030281
 protein coding gene Chr6:17410479-17455494 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030940
 protein coding gene Chr6:15037401-15082065 (-)
PWK/PhJ MGP_PWKPhJ_G0029285
 protein coding gene Chr6:14235096-14277377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029121
 protein coding gene Chr6:14923598-14965080 (-)
WSB/EiJ MGP_WSBEiJ_G0029647
 protein coding gene Chr6:14974977-15017296 (-)



Homology
more
  • Human Ortholog
    WNT2, Wnt family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT2, Wnt family member 2
  • Synonyms
    INT1L1, IRP
  • Links
    NCBI Gene ID: 7472
    neXtProt AC: NX_P09544
    UniProt: P09544

  • Chr Location
    7q31.2; chr7:117275451-117323152 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human WNT2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit impaired placental vascularization, runting and 50% perinatal mortality resulting from difficulties in breathing and nursing. Survivors of the perinatal period tend to recover, and adults are healthy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1605
  • Tissues
    494
  • cDNA Data
    27
  • Literature Summary
    158
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010797 Ensembl Gene Model | MGI Sequence Detail 41646 C57BL/6J ±  kb
    transcript ENSMUST00000010941 Ensembl | MGI Sequence Detail 2255 Not Applicable  
    polypeptide ENSMUSP00000010941 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 13
      cDNA 29
      Primer pair 24
      Other 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11475, MGD-MRK-15439, MGD-MRK-15449, MGI:1919406
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 158
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:9380 Wainwright BJ, et al., Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 1988 Jun;7(6):1743-8
    • Latest
      J:345835 Qiu C, et al., A single-cell time-lapse of mouse prenatal development from gastrula to birth. Nature. 2024 Feb;626(8001):1084-1093
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory