Wnt5a MGI Mouse Gene Detail - MGI:98958 - wingless-type MMTV integration site family, member 5A

Symbol

Wnt5a
Name

wingless-type MMTV integration site family, member 5A
Synonyms

8030457G12Rik, Wnt-5a

Feature Type

protein coding gene
IDs

MGI:98958
NCBI Gene: 22418
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr14:28226707-28249405 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 16.80 cM
Mapping Data

12 experiments

SNPs within 2kb

430 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98958	protein coding gene	Chr14:28224962-28249405 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021095	protein coding gene	Chr14:21543601-21562779 (+)
A/J	MGP_AJ_G0021043	protein coding gene	Chr14:20715661-20735129 (+)
AKR/J	MGP_AKRJ_G0021020	protein coding gene	Chr14:21790686-21814655 (+)
BALB/cJ	MGP_BALBcJ_G0021047	protein coding gene	Chr14:20820543-20844052 (+)
C3H/HeJ	MGP_C3HHeJ_G0020830	protein coding gene	Chr14:21654065-21671555 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021479	protein coding gene	Chr14:22424363-22443775 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019042	protein coding gene	Chr14:20830611-20852064 (+)
CAST/EiJ	MGP_CASTEiJ_G0020355	protein coding gene	Chr14:21338282-21357895 (+)
CBA/J	MGP_CBAJ_G0020797	protein coding gene	Chr14:23308984-23326470 (+)
DBA/2J	MGP_DBA2J_G0020919	protein coding gene	Chr14:20792067-20811952 (+)
FVB/NJ	MGP_FVBNJ_G0020903	protein coding gene	Chr14:20746459-20767722 (+)
LP/J	MGP_LPJ_G0020988	protein coding gene	Chr14:21856726-21875389 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020929	protein coding gene	Chr14:22641293-22663797 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021512	protein coding gene	Chr14:21561351-21579934 (+)
PWK/PhJ	MGP_PWKPhJ_G0020103	protein coding gene	Chr14:20208426-20230291 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019927	protein coding gene	Chr14:21102690-21120713 (+)
WSB/EiJ	MGP_WSBEiJ_G0020410	protein coding gene	Chr14:21612471-21633922 (+)

Human Ortholog

WNT5A, Wnt family member 5A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNT5A, Wnt family member 5A
Synonyms

hWNT5A
Links

HGNC:12784

NCBI Gene ID: 7474

neXtProt AC: NX_P41221

UniProt: P41221
Chr Location

3p14.3; chr3:55465715-55505263 (-) GRCh38

MGI Vertebrate Homology

Wnt5a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WNT5A
Gene Tree

Wnt5a

Diseases

1 with Wnt5a mouse models; 1 with human WNT5A associations

Human Disease

Mouse Models

Robinow syndrome

IDs

View 1 model

autosomal dominant Robinow syndrome 1

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

92 phenotypes from 5 alleles in 10 genetic backgrounds
14 phenotypes from multigenic genotypes
42 images
168 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Endonuclease-mediated

6
Targeted

8
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.

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All GO Annotations

301
GO References

75

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

2160
Tissues

840
cDNA Data

33
Literature Summary

399

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WNT5A

ZFIN wnt5a

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All Sequences

54
RefSeq

10
UniProt

1
CCDS

CCDS26888.1, CCDS56946.1

Ensembl

ENSMUSG00000021994 (Evidence)
NCBI Gene

22418

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021994	Ensembl Gene Model \| MGI Sequence Detail	22699	C57BL/6J	± kb
transcript	ENSMUST00000063465	Ensembl \| MGI Sequence Detail	7010	Not Applicable
polypeptide	ENSMUSP00000064878	Ensembl \| MGI Sequence Detail	380	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017445 protein Wnt-5a

(term hierarchy)
InterPro Domains

IPR005817 Wnt

IPR043158 Wnt, C-terminal domain

IPR018161 Wnt protein, conserved site
GlyGen

P22725 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 114

Genomic 1

cDNA 38

Primer pair 41

Other 34

Microarray probesets 8

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MGD-MRK-15443, MGD-MRK-15453, MGI:1924815

Summaries

All 633

Developmental Gene Expression 399

Diseases 1

Gene Ontology 75

Phenotypes 168
Earliest

J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
Latest

J:353578 Paramore SV, et al., Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex. Development. 2024 Aug 15;151(16):dev202692

TSS for Wnt5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124778	Chr14:28226522-28226562 (+)	-165 bp
Tssr124779	Chr14:28226591-28226613 (+)	-105 bp
Tssr124780	Chr14:28226635-28226646 (+)	-66 bp
Tssr124781	Chr14:28226693-28226719 (+)	-1 bp
Tssr124782	Chr14:28226753-28226783 (+)	61 bp
Tssr124783	Chr14:28227420-28227448 (+)	727 bp
Tssr124784	Chr14:28227452-28227466 (+)	752 bp
Tssr124785	Chr14:28227499-28227526 (+)	806 bp
Tssr124786	Chr14:28227563-28227574 (+)	862 bp
Tssr124787	Chr14:28227716-28227729 (+)	1,016 bp
Tssr124788	Chr14:28227738-28227754 (+)	1,039 bp
Tssr124789	Chr14:28227774-28227792 (+)	1,076 bp
Tssr124790	Chr14:28231747-28231777 (+)	5,055 bp
Tssr124791	Chr14:28232055-28232076 (+)	5,359 bp
Tssr124792	Chr14:28233301-28233338 (+)	6,613 bp
Tssr124793	Chr14:28248136-28248152 (+)	21,437 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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