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Wnt5b Gene Detail
Summary
  • Symbol
    Wnt5b
  • Name
    wingless-type MMTV integration site family, member 5B
  • Synonyms
    Wnt-5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:98959
    NCBI Gene: 22419
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119409492-119521308 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98959
 protein coding gene Chr6:119409492-119521847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031194
 protein coding gene Chr6:122235553-122363336 (-)
A/J MGP_AJ_G0031163
 protein coding gene Chr6:117554496-117667051 (-)
AKR/J MGP_AKRJ_G0031094
 protein coding gene Chr6:120702009-120818855 (-)
BALB/cJ MGP_BALBcJ_G0031174
 protein coding gene Chr6:117328873-117441379 (-)
C3H/HeJ MGP_C3HHeJ_G0030534
 protein coding gene Chr6:63475485-63593365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031632
 protein coding gene Chr6:125359649-125497236 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028793
 protein coding gene Chr6:114473044-114490559 (-)
CAST/EiJ MGP_CASTEiJ_G0030281
 protein coding gene Chr6:121150634-121272959 (-)
CBA/J MGP_CBAJ_G0030857
 protein coding gene Chr6:130321296-130452143 (-)
DBA/2J MGP_DBA2J_G0031013
 protein coding gene Chr6:116457082-116572302 (-)
FVB/NJ MGP_FVBNJ_G0030965
 protein coding gene Chr6:115578996-115692132 (-)
LP/J MGP_LPJ_G0031092
 protein coding gene Chr6:122243668-122366174 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030999
 protein coding gene Chr6:134330404-134456716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031661
 protein coding gene Chr6:120748310-120870499 (-)
PWK/PhJ MGP_PWKPhJ_G0029996
 protein coding gene Chr6:115465288-115587965 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029825
 protein coding gene Chr6:119463468-119589664 (-)
WSB/EiJ MGP_WSBEiJ_G0030364
 protein coding gene Chr6:121017395-121143549 (-)



Homology
more
  • Human Ortholog
    WNT5B, Wnt family member 5B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT5B, Wnt family member 5B
  • Links
    NCBI Gene ID: 81029
    neXtProt AC: NX_Q9H1J7
    UniProt: Q9H1J7

  • Chr Location
    12p13.33; chr12:1529891-1647212 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1898
  • Tissues
    623
  • cDNA Data
    52
  • Literature Summary
    97
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030170 Ensembl Gene Model | MGI Sequence Detail 111817 C57BL/6J ±  kb
    transcript ENSMUST00000119369 Ensembl | MGI Sequence Detail 2339 Not Applicable  
    polypeptide ENSMUSP00000112448 Ensembl | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 55
      Primer pair 17
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15444, MGD-MRK-15454, MGI:2141692
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 97
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
    • Latest
      J:348596 Luan Y, et al., Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis. Cell Rep. 2024 Mar 26;43(3):113934
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory