Wnt7b MGI Mouse Gene Detail - MGI:98962 - wingless-type MMTV integration site family, member 7B

Symbol

Wnt7b
Name

wingless-type MMTV integration site family, member 7B
Synonyms

Wnt-7b

Feature Type

protein coding gene
IDs

MGI:98962
NCBI Gene: 22422
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:85419638-85466022 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.39 cM
Mapping Data

4 experiments

SNPs within 2kb

1003 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98962	protein coding gene	Chr15:85419638-85466674 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022193	protein coding gene	Chr15:86417022-86465047 (-)
A/J	MGP_AJ_G0022152	protein coding gene	Chr15:83199141-83246856 (-)
AKR/J	MGP_AKRJ_G0022127	protein coding gene	Chr15:85657550-85707396 (-)
BALB/cJ	MGP_BALBcJ_G0022158	protein coding gene	Chr15:83324933-83371146 (-)
C3H/HeJ	MGP_C3HHeJ_G0021928	protein coding gene	Chr15:85595080-85644269 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022603	protein coding gene	Chr15:89652422-89704261 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020128	protein coding gene	Chr15:79525819-79572341 (-)
CAST/EiJ	MGP_CASTEiJ_G0021450	protein coding gene	Chr15:86400147-86446495 (-)
CBA/J	MGP_CBAJ_G0021895	protein coding gene	Chr15:92636140-92682221 (-)
DBA/2J	MGP_DBA2J_G0022022	protein coding gene	Chr15:82661269-82707897 (-)
FVB/NJ	MGP_FVBNJ_G0022001	protein coding gene	Chr15:81732387-81780870 (-)
LP/J	MGP_LPJ_G0022093	protein coding gene	Chr15:86582700-86630547 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022021	protein coding gene	Chr15:97331454-97381879 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022618	protein coding gene	Chr15:85654153-85700341 (-)
PWK/PhJ	MGP_PWKPhJ_G0021191	protein coding gene	Chr15:82671339-82718476 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021025	protein coding gene	Chr15:85356034-85403930 (-)
WSB/EiJ	MGP_WSBEiJ_G0021499	protein coding gene	Chr15:86151827-86200730 (-)

Human Ortholog

WNT7B, Wnt family member 7B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNT7B, Wnt family member 7B
Links

HGNC:12787

NCBI Gene ID: 7477

neXtProt AC: NX_P56706

UniProt: P56706
Chr Location

22q13.31; chr22:45920366-45977162 (-) GRCh38

MGI Vertebrate Homology

Wnt7b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WNT7B
Gene Tree

Wnt7b

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References

1 with disease annotations

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Phenotype Summary

39 phenotypes from 5 alleles in 6 genetic backgrounds
6 phenotypes from multigenic genotypes
56 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

2
Radiation induced

2
Targeted

8
Genomic Mutations

3 involving Wnt7b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.

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All GO Annotations

75
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1852
Tissues

604
cDNA Data

66
Literature Summary

277

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WNT7B

Xenbase wnt7b

ZFIN wnt7ba, wnt7bb

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All Sequences

51
RefSeq

6
UniProt

5
CCDS

CCDS37171.1, CCDS49691.1, CCDS49692.1

Ensembl

ENSMUSG00000022382 (Evidence)
NCBI Gene

22422

			Length	Strain/Species	Flank
genomic	22422	NCBI Gene Model \| MGI Sequence Detail	46385	C57BL/6J	± kb
transcript	NM_001163634	RefSeq \| MGI Sequence Detail	3510	ZRU/MplStud
polypeptide	P28047	UniProt \| EBI \| MGI Sequence Detail	349	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017449 protein Wnt-7b

(term hierarchy)
InterPro Domains

IPR005817 Wnt

IPR013300 Wnt-7 protein

IPR043158 Wnt, C-terminal domain

IPR018161 Wnt protein, conserved site
GlyGen

P28047 5 sites, 3 N-linked glycans (3 sites)

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All nucleic 118

cDNA 72

Primer pair 24

Other 22

Microarray probesets 5

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MGD-MRK-15447, MGD-MRK-15457

Summaries

All 376

Developmental Gene Expression 277

Diseases 1

Gene Ontology 22

Phenotypes 56
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:347411 Kimura E, et al., MAP3K1 regulates female reproductive tract development. Dis Model Mech. 2024 Mar 1;17(3)

TSS for Wnt7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135760	Chr15:85466128-85466150 (-)	-117 bp
Tssr135759	Chr15:85466037-85466114 (-)	-54 bp
Tssr4683	Chr15:85466026-85466033 (-)	-8 bp
Tssr135758	Chr15:85466010-85466021 (-)	6 bp
Tssr135757	Chr15:85462337-85462355 (-)	3,676 bp
Tssr135756	Chr15:85462320-85462333 (-)	3,695 bp
Tssr135755	Chr15:85462070-85462103 (-)	3,935 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24