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Yy1 Gene Detail
Summary
  • Symbol
    Yy1
  • Name
    YY1 transcription factor
  • Synonyms
    delta transcription factor, NF-E1, UCRBP transcription factor, Yin Yang 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99150
    NCBI Gene: 22632
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108758899-108786074 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.58 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99150
 protein coding gene Chr12:108758841-108786074 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020108
 protein coding gene Chr12:110949677-110974740 (+)
A/J MGP_AJ_G0020062
 protein coding gene Chr12:106728310-106751975 (+)
AKR/J MGP_AKRJ_G0020038
 protein coding gene Chr12:109820972-109845181 (+)
BALB/cJ MGP_BALBcJ_G0020048
 protein coding gene Chr12:107154311-107177856 (+)
C3H/HeJ MGP_C3HHeJ_G0019850
 protein coding gene Chr12:110274295-110299793 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020493
 protein coding gene Chr12:114363882-114388764 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018105
 protein coding gene Chr12:103249895-103271504 (+)
CAST/EiJ MGP_CASTEiJ_G0019392
 protein coding gene Chr12:105217002-105242837 (+)
CBA/J MGP_CBAJ_G0019817
 protein coding gene Chr12:118924457-118954387 (+)
DBA/2J MGP_DBA2J_G0019934
 protein coding gene Chr12:106267677-106291343 (+)
FVB/NJ MGP_FVBNJ_G0019919
 protein coding gene Chr12:105052200-105075804 (+)
LP/J MGP_LPJ_G0020009
 protein coding gene Chr12:110812981-110837693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019957
 protein coding gene Chr12:122069895-122095732 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020522
 protein coding gene Chr12:109306923-109332554 (+)
PWK/PhJ MGP_PWKPhJ_G0019151
 protein coding gene Chr12:100886976-100915518 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018955
 protein coding gene Chr12:103513628-103538309 (+)
WSB/EiJ MGP_WSBEiJ_G0019449
 protein coding gene Chr12:110242957-110269311 (+)



Homology
more
  • Human Ortholog
    YY1, YY1 transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YY1, YY1 transcription factor
  • Synonyms
    DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1
  • Links
    NCBI Gene ID: 7528
    neXtProt AC: NX_P25490
    UniProt: P25490

  • Chr Location
    14q32.2; chr14:100238298-100282788 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Yy1 mouse models; 1 with human YY1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 4 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die in utero shortly after implantation. Incomplete penetrance of embryonic growth retardation and exencephaly are observed in haploinsufficient mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    239
  • cDNA Data
    14
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021264 Ensembl Gene Model | MGI Sequence Detail 27176 C57BL/6J ±  kb
    transcript ENSMUST00000021692 Ensembl | MGI Sequence Detail 6178 Not Applicable  
    polypeptide ENSMUSP00000021692 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 7
      cDNA 15
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15848, MGI:2145026
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 39
      Diseases 1
      Gene Ontology 30
      Phenotypes 69
    • Earliest
      J:2309 Flanagan JR, et al., Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. Mol Cell Biol. 1992 Jan;12(1):38-44
    • Latest
      J:352717 Pereira A, et al., Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1. Nat Neurosci. 2024 Jul;27(7):1260-1273
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory