Zfp35 MGI Mouse Gene Detail - MGI:99179

Symbol

Zfp35
Name

zinc finger protein 35
Synonyms

Zfp-35

Feature Type

protein coding gene
IDs

MGI:99179
NCBI Gene: 22694
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr18:24122689-24138433 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 12.51 cM, cytoband B3-C
Mapping Data

1 experiment

SNPs within 2kb

474 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99179	protein coding gene	Chr18:24122134-24138433 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024196	protein coding gene	Chr18:21703787-21719401 (+)
A/J	MGP_AJ_G0024161	protein coding gene	Chr18:21120235-21135898 (+)
AKR/J	MGP_AKRJ_G0024130	protein coding gene	Chr18:21762605-21779132 (+)
BALB/cJ	MGP_BALBcJ_G0024161	protein coding gene	Chr18:21163471-21181922 (+)
C3H/HeJ	MGP_C3HHeJ_G0023929	protein coding gene	Chr18:21694583-21711845 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024603	protein coding gene	Chr18:22638550-22655116 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022045	protein coding gene	Chr18:20991125-21006615 (+)
CAST/EiJ	MGP_CASTEiJ_G0023403	protein coding gene	Chr18:21467708-21484661 (+)
CBA/J	MGP_CBAJ_G0023897	protein coding gene	Chr18:23239450-23257651 (+)
DBA/2J	MGP_DBA2J_G0024029	protein coding gene	Chr18:20794956-20810575 (+)
FVB/NJ	MGP_FVBNJ_G0023995	protein coding gene	Chr18:20547805-20566803 (+)
LP/J	MGP_LPJ_G0024110	protein coding gene	Chr18:21876747-21893074 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024023	protein coding gene	Chr18:24267039-24285977 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024651	protein coding gene	Chr18:21517717-21533333 (+)
PWK/PhJ	MGP_PWKPhJ_G0023147	protein coding gene	Chr18:20925152-20943794 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022956	protein coding gene	Chr18:21744144-21761958 (+)
WSB/EiJ	MGP_WSBEiJ_G0023467	protein coding gene	Chr18:21411974-21428277 (+)

less

MGI Vertebrate Homology

Zfp35 stringent orthology
1 mouse;1 rat
Gene Tree

Zfp35

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

4
Gene trapped

16
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out mutation exhibit increased airway responsiveness to ovalbumin and methacholine.

less

All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

53
cDNA Data

58
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

45
RefSeq

4
UniProt

7
CCDS

CCDS29097.1

Ensembl

ENSMUSG00000063281 (Evidence)
NCBI Gene

22694

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063281	Ensembl Gene Model \| MGI Sequence Detail	15745	C57BL/6J	± kb
transcript	ENSMUST00000074941	Ensembl \| MGI Sequence Detail	3040	Not Applicable
polypeptide	ENSMUSP00000074475	Ensembl \| MGI Sequence Detail	580	Not Applicable

less

UniProt

7 Sequences
InterPro Domains

IPR050329 GLI C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

less

All nucleic 64

Genomic 4

cDNA 58

Primer pair 1

Other 1

Microarray probesets 3

less

MGD-MRK-15876, MGD-MRK-15931

Summaries

All 34

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 8
Earliest

J:10190 Cunliffe V, et al., A mouse zinc finger gene which is transiently expressed during spermatogenesis. EMBO J. 1990 Jan;9(1):197-205
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Zfp35:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150277	Chr18:24122709-24122751 (+)	41 bp
Tssr150278	Chr18:24132402-24132409 (+)	9,717 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24