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Zfp46 Gene Detail
Summary
  • Symbol
    Zfp46
  • Name
    zinc finger protein 46
  • Synonyms
    Zfp-46
  • Feature Type
    protein coding gene
  • IDs
    MGI:99192
    NCBI Gene: 22704
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136011994-136021253 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99192
 protein coding gene Chr4:136011479-136021253 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028964
 protein coding gene Chr4:138823468-138836597 (+)
A/J MGP_AJ_G0028923
 protein coding gene Chr4:132918588-132927880 (+)
AKR/J MGP_AKRJ_G0028875
 protein coding gene Chr4:136762641-136771921 (+)
BALB/cJ MGP_BALBcJ_G0028947
 protein coding gene Chr4:133580480-133589780 (+)
C3H/HeJ MGP_C3HHeJ_G0028661
 protein coding gene Chr4:137037916-137047212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029388
 protein coding gene Chr4:143751707-143760966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026659
 protein coding gene Chr4:125953396-125962902 (+)
CAST/EiJ MGP_CASTEiJ_G0028093
 protein coding gene Chr4:135186089-135195339 (+)
CBA/J MGP_CBAJ_G0028626
 protein coding gene Chr4:147691207-147700489 (+)
DBA/2J MGP_DBA2J_G0028775
 protein coding gene Chr4:133337432-133346738 (+)
FVB/NJ MGP_FVBNJ_G0028742
 protein coding gene Chr4:132281905-132291213 (+)
LP/J MGP_LPJ_G0028874
 protein coding gene Chr4:138912963-138922495 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028768
 protein coding gene Chr4:151926524-151935830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029426
 protein coding gene Chr4:137219449-137228991 (+)
PWK/PhJ MGP_PWKPhJ_G0027813
 protein coding gene Chr4:130115319-130124611 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027639
 protein coding gene Chr4:133043594-133054071 (+)
WSB/EiJ MGP_WSBEiJ_G0028171
 protein coding gene Chr4:137391520-137400792 (+)



Homology
more
  • Human Ortholog
    ZNF436, zinc finger protein 436
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF436, zinc finger protein 436
  • Synonyms
    Zfp46, ZNF
  • Links
    NCBI Gene ID: 80818
    neXtProt AC: NX_Q9C0F3
    UniProt: Q9C0F3

  • Chr Location
    1p36.12; chr1:23359448-23369836 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Zfp46
  • Find Mice (IMSR)
    9 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    50
  • cDNA Data
    80
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051351 Ensembl Gene Model | MGI Sequence Detail 9260 C57BL/6J ±  kb
transcript ENSMUST00000069195 Ensembl | MGI Sequence Detail 4639 Not Applicable  
polypeptide ENSMUSP00000070216 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    cDNA 80
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15889, MGD-MRK-15944, MGI:2140266
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:4069 Brady JP, et al., Cloning and characterization of a novel zinc-finger protein-encoding cDNA from the mouse eye lens. Gene. 1993 Feb 28;124(2):207-14
  • Latest
    J:190636 Wiese CB, et al., A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory