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Zfx Gene Detail
Summary
  • Symbol
    Zfx
  • Name
    zinc finger protein X-linked
  • Synonyms
    Zfx5, Zfx5,6, Zfx6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99211
    NCBI Gene: 22764
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:93118237-93167308 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.48 cM, cytoband D
  • Mapping Data
    37 experiments
Strain
Comparison
more
  • SNPs within 2kb
    878 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99211
 protein coding gene ChrX:93118237-93194250 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035907
 protein coding gene ChrX:90460729-90510604 (-)
A/J MGP_AJ_G0035893
 protein coding gene ChrX:90557721-90608250 (-)
AKR/J MGP_AKRJ_G0035810
 protein coding gene ChrX:92947766-92999586 (-)
BALB/cJ MGP_BALBcJ_G0035877
 protein coding gene ChrX:89271770-89315472 (-)
C3H/HeJ MGP_C3HHeJ_G0035586
 protein coding gene ChrX:90824686-90879612 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036406
 protein coding gene ChrX:93222974-93278300 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033233
 protein coding gene ChrX:88714552-88764341 (-)
CAST/EiJ MGP_CASTEiJ_G0034871
 protein coding gene ChrX:75490802-75546887 (-)
CBA/J MGP_CBAJ_G0035560
 protein coding gene ChrX:95915829-95970488 (-)
DBA/2J MGP_DBA2J_G0035716
 protein coding gene ChrX:89796883-89847039 (-)
FVB/NJ MGP_FVBNJ_G0035655
 protein coding gene ChrX:89188347-89239975 (-)
LP/J MGP_LPJ_G0035804
 protein coding gene ChrX:91247248-91299102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035689
 protein coding gene ChrX:100216575-100258624 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036433
 protein coding gene ChrX:90179965-90231912 (-)
PWK/PhJ MGP_PWKPhJ_G0034570
 protein coding gene ChrX:73280541-73330988 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034400
 protein coding gene ChrX:76375047-76402441 (-)
WSB/EiJ MGP_WSBEiJ_G0035012
 protein coding gene ChrX:88981056-89029786 (-)



Homology
more
  • Human Ortholog
    ZFX, zinc finger protein X-linked
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFX, zinc finger protein X-linked
  • Synonyms
    MRXS37, ZNF926
  • Links
    NCBI Gene ID: 7543
    neXtProt AC: NX_P17010
    UniProt: P17010

  • Chr Location
    Xp22.11; chrX:24148982-24216255 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZFX associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 8 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous or female mice homozygous for one knock-out allele exhibit reduced size, viability, and gametes. Another knock-out allele generates mice that exhibit embryonic lethality associated with abnormal extraembryonic tissue and reduction in hematopoietic stem cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    144
  • cDNA Data
    80
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079509 Ensembl Gene Model | MGI Sequence Detail 49072 C57BL/6J ±  kb
    transcript ENSMUST00000088102 Ensembl | MGI Sequence Detail 7002 Not Applicable  
    polypeptide ENSMUSP00000085423 Ensembl | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      Genomic 30
      cDNA 83
      Primer pair 1
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-15963, MGI:1096553, MGI:1096556
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:9551 Nagamine CM, et al., Chromosome mapping and expression of a putative testis-determining gene in mouse. Science. 1989 Jan 6;243(4887):80-3
    • Latest
      J:248998 Zhang Y, et al., RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis. Mamm Genome. 2017 Apr;28(3-4):100-105
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory