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Zp3 Gene Detail
Summary
  • Symbol
    Zp3
  • Name
    zona pellucida glycoprotein 3
  • Synonyms
    Zp-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99215
    NCBI Gene: 22788
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136008959-136017478 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.62 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    3
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99215
 protein coding gene Chr5:136008953-136017478 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030195
 protein coding gene Chr5:140587314-140597732 (+)
A/J MGP_AJ_G0030163
 protein coding gene Chr5:134541219-134549685 (+)
AKR/J MGP_AKRJ_G0030096
 protein coding gene Chr5:138892273-138900701 (+)
BALB/cJ MGP_BALBcJ_G0030173
 protein coding gene Chr5:135898142-135906532 (+)
C3H/HeJ MGP_C3HHeJ_G0029889
 protein coding gene Chr5:139500028-139508415 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030626
 protein coding gene Chr5:145816252-145825723 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029299
 protein coding gene Chr5:138897501-138906509 (+)
CBA/J MGP_CBAJ_G0029859
 protein coding gene Chr5:151501056-151509404 (+)
DBA/2J MGP_DBA2J_G0030010
 protein coding gene Chr5:134443232-134452637 (+)
FVB/NJ MGP_FVBNJ_G0029965
 protein coding gene Chr5:133590365-133600832 (+)
LP/J MGP_LPJ_G0030099
 protein coding gene Chr5:141014123-141023809 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029997
 protein coding gene Chr5:154492766-154503426 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030666
 protein coding gene Chr5:138688780-138698677 (+)
PWK/PhJ MGP_PWKPhJ_G0029012
 protein coding gene Chr5:133501463-133510086 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028848
 protein coding gene Chr5:136239859-136250973 (+)
WSB/EiJ MGP_WSBEiJ_G0029372
 protein coding gene Chr5:139425296-139433982 (+)



Homology
more
  • Human Ortholog
    ZP3, zona pellucida glycoprotein 3
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZP3, zona pellucida glycoprotein 3
  • Synonyms
    OOMD3, OZEMA3, Zp-3, ZP3A, ZP3B, ZPC
  • Links
    NCBI Gene ID: 7784
    neXtProt AC: NX_P21754
    UniProt: P21754

  • Chr Location
    7q11.23; chr7:76397518-76442071 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous female mutants are infertile. In these females oocytes lack a zona pellucida and cumulus-oocyte complexes are disrupted. Oocytes of heterozygous females have a thin zona, but females are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    6
  • cDNA Data
    31
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22788 NCBI Gene Model | MGI Sequence Detail 8520 C57BL/6J ±  kb
    transcript NM_011776 RefSeq | MGI Sequence Detail 1317 NIH Swiss  
    polypeptide P10761 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 15
      cDNA 31
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15969, MGD-MRK-15971
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 17
      Gene Ontology 19
      Phenotypes 18
    • Earliest
      J:8308 Ringuette MJ, et al., Oocyte-specific gene expression: molecular characterization of a cDNA coding for ZP-3, the sperm receptor of the mouse zona pellucida. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4341-5
    • Latest
      J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory