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Cdh11 Gene Detail
Summary
  • Symbol
    Cdh11
  • Name
    cadherin 11
  • Synonyms
    Cad11, OB-cadherin, osteoblast-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:99217
    NCBI Gene: 12552
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:103358727-103512125 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 50.44 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4809 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99217
 protein coding gene Chr8:103358727-103512274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033997
 protein coding gene Chr8:104502904-104685229 (-)
A/J MGP_AJ_G0033980
 protein coding gene Chr8:100378535-100447086 (-)
AKR/J MGP_AKRJ_G0033906
 protein coding gene Chr8:103280109-103480617 (-)
BALB/cJ MGP_BALBcJ_G0033972
 protein coding gene Chr8:100612295-100784024 (-)
C3H/HeJ MGP_C3HHeJ_G0033683
 protein coding gene Chr8:103973063-104150327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034494
 protein coding gene Chr8:108398534-108472926 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031435
 protein coding gene Chr8:93839263-93996701 (-)
CAST/EiJ MGP_CASTEiJ_G0033014
 protein coding gene Chr8:103597567-103660562 (-)
CBA/J MGP_CBAJ_G0033658
 protein coding gene Chr8:112012212-112202003 (-)
DBA/2J MGP_DBA2J_G0033812
 protein coding gene Chr8:99817165-99998146 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033801
 protein coding gene Chr8:115169564-115364549 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034511
 protein coding gene Chr8:103336771-103520778 (-)
PWK/PhJ MGP_PWKPhJ_G0032716
 protein coding gene Chr8:99231003-99408925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032553
 protein coding gene Chr8:102184170-102301060 (-)
WSB/EiJ MGP_WSBEiJ_G0033126
 protein coding gene Chr8:103929171-103990627 (-)



Homology
more
  • Human Ortholog
    CDH11, cadherin 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH11, cadherin 11
  • Synonyms
    CAD11, CDHOB, ESWS, OB, OSF-4, TBHS2
  • Links
    NCBI Gene ID: 1009
    neXtProt AC: NX_P55287
    UniProt: P55287

  • Chr Location
    16q21; chr16:64943753-65126112 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CDH11 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals appear healthy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1458
  • Tissues
    545
  • cDNA Data
    92
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12552 NCBI Gene Model | MGI Sequence Detail 153399 C57BL/6J ±  kb
    transcript NM_009866 RefSeq | MGI Sequence Detail 5080 ZRU/MplStud  
    polypeptide P55288 UniProt | EBI | MGI Sequence Detail 796 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      Genomic 2
      cDNA 99
      Primer pair 9
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15974
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 69
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:17789 Okazaki M, et al., Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem. 1994 Apr 22;269(16):12092-8
    • Latest
      J:349163 Huycke TR, et al., Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024 Jun 6;187(12):3072-3089.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory