About   Help   FAQ
Egr4 Gene Detail
Summary
  • Symbol
    Egr4
  • Name
    early growth response 4
  • Synonyms
    NGF1-C, NGFI-C, pAT133
  • Feature Type
    protein coding gene
  • IDs
    MGI:99252
    NCBI Gene: 13656
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85488103-85490571 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99252
 protein coding gene Chr6:85488103-85490571 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030957
 protein coding gene Chr6:86682201-86684669 (-)
A/J MGP_AJ_G0030926
 protein coding gene Chr6:83381622-83384090 (-)
AKR/J MGP_AKRJ_G0030854
 protein coding gene Chr6:85800581-85803049 (-)
BALB/cJ MGP_BALBcJ_G0030936
 protein coding gene Chr6:83373362-83375830 (-)
C3H/HeJ MGP_C3HHeJ_G0030774
 protein coding gene Chr6:98645680-98648148 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031396
 protein coding gene Chr6:89066123-89068591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028581
 protein coding gene Chr6:81654617-81657094 (-)
CAST/EiJ MGP_CASTEiJ_G0030045
 protein coding gene Chr6:85815365-85817697 (-)
CBA/J MGP_CBAJ_G0030623
 protein coding gene Chr6:92551331-92553799 (-)
DBA/2J MGP_DBA2J_G0030776
 protein coding gene Chr6:82664004-82666472 (-)
FVB/NJ MGP_FVBNJ_G0030729
 protein coding gene Chr6:81866227-81868695 (-)
LP/J MGP_LPJ_G0030855
 protein coding gene Chr6:86673430-86675898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030765
 protein coding gene Chr6:96764759-96767227 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031420
 protein coding gene Chr6:85602151-85604619 (-)
PWK/PhJ MGP_PWKPhJ_G0029760
 protein coding gene Chr6:81598790-81601101 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029588
 protein coding gene Chr6:84456819-84461861 (-)
WSB/EiJ MGP_WSBEiJ_G0030126
 protein coding gene Chr6:86047296-86049764 (-)



Homology
more
  • Human Ortholog
    EGR4, early growth response 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGR4, early growth response 4
  • Synonyms
    AT133, NGFI-C, NGFIC, PAT133
  • Links
    NCBI Gene ID: 1961
    neXtProt AC: NX_Q05215
    UniProt: Q05215

  • Chr Location
    2p13.2; chr2:73290929-73293701 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male homozygous null mice are viable but infertile due to an impairment of meiosis during spermatogenesis. Females are fertile and the gross anatomy of both sexes appears normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    56
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13656 NCBI Gene Model | MGI Sequence Detail 2469 C57BL/6J ±  kb
    transcript NM_020596 RefSeq | MGI Sequence Detail 2161 ZRU/MplStud  
    polypeptide Q9WUF2 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16010
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:1017 Crosby SD, et al., Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C [published erratum appears in Proc Natl Acad Sci U S A 1992 Jul 15;89(14):6663]. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4739-43
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory