Etv1 MGI Mouse Gene Detail - MGI:99254

Symbol

Etv1
Name

ets variant 1
Synonyms

ER81, Etsrp81

Feature Type

protein coding gene
IDs

MGI:99254
NCBI Gene: 14009
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr12:38829655-38920484 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 17.99 cM
Mapping Data

4 experiments

SNPs within 2kb

2478 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99254	protein coding gene	Chr12:38829379-38920484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019698	protein coding gene	Chr12:37103158-37198363 (+)
A/J	MGP_AJ_G0019664	protein coding gene	Chr12:35901164-35991637 (+)
AKR/J	MGP_AKRJ_G0019635	protein coding gene	Chr12:37015821-37105115 (+)
BALB/cJ	MGP_BALBcJ_G0019642	protein coding gene	Chr12:36138640-36228270 (+)
C3H/HeJ	MGP_C3HHeJ_G0019446	protein coding gene	Chr12:36928173-37021262 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020089	protein coding gene	Chr12:38245448-38338703 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017714	protein coding gene	Chr12:34961077-35049581 (+)
CAST/EiJ	MGP_CASTEiJ_G0018999	protein coding gene	Chr12:32076109-32168496 (+)
CBA/J	MGP_CBAJ_G0019418	protein coding gene	Chr12:39493656-39585951 (+)
DBA/2J	MGP_DBA2J_G0019531	protein coding gene	Chr12:35779557-35870883 (+)
FVB/NJ	MGP_FVBNJ_G0019520	protein coding gene	Chr12:35451374-35540909 (+)
LP/J	MGP_LPJ_G0019601	protein coding gene	Chr12:37175356-37263789 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019556	protein coding gene	Chr12:39534977-39628815 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020129	protein coding gene	Chr12:36574720-36666785 (+)
PWK/PhJ	MGP_PWKPhJ_G0018766	protein coding gene	Chr12:30443838-30533921 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018556	protein coding gene	Chr12:31216136-31306039 (+)
WSB/EiJ	MGP_WSBEiJ_G0019049	protein coding gene	Chr12:36858240-36949782 (+)

Human Ortholog

ETV1, ETS variant transcription factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ETV1, ETS variant transcription factor 1
Synonyms

ER81
Links

HGNC:3490

NCBI Gene ID: 2115

neXtProt AC: NX_P50549

UniProt: P50549
Chr Location

7p21.2; chr7:13891229-13991425 (-) GRCh38

MGI Vertebrate Homology

Etv1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ETV1
Gene Tree

Etv1

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Phenotype Summary

23 phenotypes from 5 alleles in 7 genetic backgrounds
10 phenotypes from multigenic genotypes
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous inactivation of this gene leads to premature death, ataxia, impaired limb coordination, defects in muscle innervation, muscle spindle differentiation and sensory-motor connectivity, deficient golgi tendon organs, and absence of Pacinian corpuscles and their afferents.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1271
Tissues

331
cDNA Data

57
Literature Summary

249

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ETV1

Xenbase etv1

ZFIN etv1

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All Sequences

98
RefSeq

26
UniProt

10
CCDS

CCDS49053.1, CCDS49054.1, CCDS83959.1

Ensembl

ENSMUSG00000004151 (Evidence)
NCBI Gene

14009

			Length	Strain/Species	Flank
genomic	14009	NCBI Gene Model \| MGI Sequence Detail	90830	C57BL/6J	± kb
transcript	NM_007960	RefSeq \| MGI Sequence Detail	4322	ZRU/MplStud
polypeptide	P41164	UniProt \| EBI \| MGI Sequence Detail	477	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000007223 ETS translocation variant 1

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR006715 PEA3-type ETS-domain transcription factor, N-terminal

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 81

cDNA 61

Primer pair 8

Other 12

Microarray probesets 6

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MGD-MRK-16012

Summaries

All 340

Developmental Gene Expression 249

Gene Ontology 6

Phenotypes 64
Earliest

J:19172 Brown TA, et al., Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992 Dec;6(12B):2502-12
Latest

J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602

TSS for Etv1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113280	Chr12:38830103-38830116 (+)	455 bp
Tssr113281	Chr12:38830253-38830260 (+)	602 bp
Tssr113282	Chr12:38830285-38830325 (+)	650 bp
Tssr113283	Chr12:38830816-38830853 (+)	1,180 bp
Tssr3827	Chr12:38831072-38831087 (+)	1,425 bp
Tssr113284	Chr12:38831092-38831127 (+)	1,455 bp
Tssr3828	Chr12:38833416-38833419 (+)	3,763 bp
Tssr113285	Chr12:38833454-38833481 (+)	3,813 bp
Tssr113286	Chr12:38833487-38833494 (+)	3,836 bp
Tssr113287	Chr12:38833502-38833526 (+)	3,859 bp
Tssr113288	Chr12:38833618-38833661 (+)	3,985 bp
Tssr113289	Chr12:38833672-38833683 (+)	4,023 bp
Tssr113290	Chr12:38833702-38833721 (+)	4,057 bp
Tssr113291	Chr12:38834366-38834410 (+)	4,733 bp
Tssr113292	Chr12:38879752-38879756 (+)	50,099 bp
Tssr113293	Chr12:38911016-38911025 (+)	81,366 bp
Tssr113294	Chr12:38911026-38911065 (+)	81,391 bp
Tssr113295	Chr12:38918023-38918038 (+)	88,376 bp
Tssr113296	Chr12:38918150-38918157 (+)	88,499 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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