Hdlbp MGI Mouse Gene Detail - MGI:99256 - high density lipoprotein (HDL) binding protein

Symbol

Hdlbp
Name

high density lipoprotein (HDL) binding protein
Synonyms

1110005P14Rik, D1Ertd101e

Feature Type

protein coding gene
IDs

MGI:99256
NCBI Gene: 110611
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:93333662-93406537 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.24 cM
Mapping Data

9 experiments

SNPs within 2kb

1253 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99256	protein coding gene	Chr1:93333662-93406639 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016342	protein coding gene	Chr1:95030987-95104694 (-)
A/J	MGP_AJ_G0016323	protein coding gene	Chr1:91623664-91696869 (-)
AKR/J	MGP_AKRJ_G0016284	protein coding gene	Chr1:94330575-94407436 (-)
BALB/cJ	MGP_BALBcJ_G0016279	protein coding gene	Chr1:91806409-91880919 (-)
C3H/HeJ	MGP_C3HHeJ_G0016108	protein coding gene	Chr1:94584549-94660660 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016738	protein coding gene	Chr1:98645242-98719734 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014456	protein coding gene	Chr1:85881206-85952205 (-)
CAST/EiJ	MGP_CASTEiJ_G0015691	protein coding gene	Chr1:93914748-93991458 (-)
CBA/J	MGP_CBAJ_G0016082	protein coding gene	Chr1:101838184-101912587 (-)
DBA/2J	MGP_DBA2J_G0016187	protein coding gene	Chr1:90819249-90893241 (-)
FVB/NJ	MGP_FVBNJ_G0016186	protein coding gene	Chr1:89895486-89969144 (-)
LP/J	MGP_LPJ_G0016258	protein coding gene	Chr1:96208212-96283830 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016211	protein coding gene	Chr1:104939985-105019229 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016777	protein coding gene	Chr1:94345206-94421780 (-)
PWK/PhJ	MGP_PWKPhJ_G0015476	protein coding gene	Chr1:90259002-90332749 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015260	protein coding gene	Chr1:93297640-93370196 (-)
WSB/EiJ	MGP_WSBEiJ_G0015751	protein coding gene	Chr1:94165293-94240808 (-)

Human Ortholog

HDLBP, high density lipoprotein binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HDLBP, high density lipoprotein binding protein
Synonyms

HBP, PRO2900, VGL
Links

HGNC:4857

NCBI Gene ID: 3069

neXtProt AC: NX_Q00341

UniProt: Q00341
Chr Location

2q37.3; chr2:241227264-241317061 (-) GRCh38

MGI Vertebrate Homology

Hdlbp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HDLBP
Gene Tree

Hdlbp

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

68
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

61
Radiation induced

1
Genomic Mutations

2 involving Hdlbp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

88 strains or lines available

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

47
cDNA Data

790
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hdlbp

ZFIN hdlbpa, hdlbpb

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All Sequences

112
RefSeq

24
UniProt

11
CCDS

CCDS15189.1

Ensembl

ENSMUSG00000034088 (Evidence)
NCBI Gene

110611

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034088	Ensembl Gene Model \| MGI Sequence Detail	72876	C57BL/6J	± kb
transcript	ENSMUST00000042498	Ensembl \| MGI Sequence Detail	4427	Not Applicable
polypeptide	ENSMUSP00000043047	Ensembl \| MGI Sequence Detail	1268	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000008494 vigilin

(term hierarchy)
InterPro Domains

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily
GlyGen

Q8VDJ3 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 793

cDNA 791

Primer pair 2

Microarray probesets 9

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MGD-MRK-16015, MGI:1098739, MGI:1915697, MGI:2138139, MGI:2138160

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hdlbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13033	Chr1:93406584-93406590 (-)	-50 bp
Tssr13032	Chr1:93406507-93406545 (-)	11 bp
Tssr13031	Chr1:93406051-93406113 (-)	455 bp
Tssr13030	Chr1:93373364-93373382 (-)	33,164 bp
Tssr13029	Chr1:93373144-93373158 (-)	33,386 bp
Tssr13028	Chr1:93369584-93369585 (-)	36,952 bp
Tssr13027	Chr1:93357199-93357211 (-)	49,332 bp
Tssr13026	Chr1:93357122-93357140 (-)	49,406 bp
Tssr13025	Chr1:93355939-93355955 (-)	50,590 bp
Tssr13024	Chr1:93353085-93353110 (-)	53,439 bp
Tssr13023	Chr1:93353008-93353039 (-)	53,513 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24