About   Help   FAQ
Ptgds Gene Detail
Summary
  • Symbol
    Ptgds
  • Name
    prostaglandin D2 synthase (brain)
  • Synonyms
    L-PGDS, PGD2, Ptgs3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99261
    NCBI Gene: 19215
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25356721-25360058 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.28 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99261
 protein coding gene Chr2:25356721-25360080 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025449
 protein coding gene Chr2:23355298-23360269 (-)
A/J MGP_AJ_G0025426
 protein coding gene Chr2:22452513-22455843 (-)
AKR/J MGP_AKRJ_G0025396
 protein coding gene Chr2:23199332-23202666 (-)
BALB/cJ MGP_BALBcJ_G0025422
 protein coding gene Chr2:22564044-22567797 (-)
C3H/HeJ MGP_C3HHeJ_G0025183
 protein coding gene Chr2:23147853-23151192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025866
 protein coding gene Chr2:24101547-24104925 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023277
 protein coding gene Chr2:21362470-21365794 (-)
CAST/EiJ MGP_CASTEiJ_G0024646
 protein coding gene Chr2:23017556-23021251 (-)
CBA/J MGP_CBAJ_G0025161
 protein coding gene Chr2:24935087-24938677 (-)
DBA/2J MGP_DBA2J_G0025294
 protein coding gene Chr2:22290201-22293571 (-)
FVB/NJ MGP_FVBNJ_G0025256
 protein coding gene Chr2:22034611-22038064 (-)
LP/J MGP_LPJ_G0025380
 protein coding gene Chr2:23296485-23300828 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025287
 protein coding gene Chr2:25131803-25135133 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025925
 protein coding gene Chr2:23154153-23157473 (-)
PWK/PhJ MGP_PWKPhJ_G0024394
 protein coding gene Chr2:22112264-22115630 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024194
 protein coding gene Chr2:23295024-23298365 (-)
WSB/EiJ MGP_WSBEiJ_G0024715
 protein coding gene Chr2:23230641-23233969 (-)



Homology
more
  • Human Ortholog
    PTGDS, prostaglandin D2 synthase
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGDS, prostaglandin D2 synthase
  • Synonyms
    L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2
  • Links
    NCBI Gene ID: 5730
    neXtProt AC: NX_P41222
    UniProt: P41222

  • Chr Location
    9q34.3; chr9:136975092-136981742 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTGDS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele fail to exhibit PGE2- and bicuculline-induced allodynia and exhibit decreased susceptibility to IgE-induced PCA. Mice homozygous for another knock-out allele show normal induction of muscle injury after reperfusion of ischemic skeletal muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1106
  • Tissues
    177
  • cDNA Data
    92
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015090 Ensembl Gene Model | MGI Sequence Detail 3338 C57BL/6J ±  kb
    transcript ENSMUST00000015234 Ensembl | MGI Sequence Detail 901 Not Applicable  
    polypeptide ENSMUSP00000015234 Ensembl | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 96
      Primer pair 13
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13666, MGD-MRK-16020
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 57
      Gene Ontology 12
      Phenotypes 40
    • Earliest
      J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory