Rpl22 MGI Mouse Gene Detail - MGI:99262

Symbol

Rpl22
Name

ribosomal protein L22
Synonyms

2700038K18Rik

Feature Type

protein coding gene
IDs

MGI:99262
NCBI Gene: 19934
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:152410199-152418528 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 83.03 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

335 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99262	protein coding gene	Chr4:152408893-152418539 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029180	protein coding gene	Chr4:156438480-156447394 (+)
A/J	MGP_AJ_G0029145	protein coding gene	Chr4:149885048-149893497 (+)
AKR/J	MGP_AKRJ_G0029093	protein coding gene	Chr4:153954572-153962901 (+)
BALB/cJ	MGP_BALBcJ_G0029161	protein coding gene	Chr4:150351687-150360016 (+)
C3H/HeJ	MGP_C3HHeJ_G0028882	protein coding gene	Chr4:154521666-154531537 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029610	protein coding gene	Chr4:162051097-162059426 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026856	protein coding gene	Chr4:142224498-142233194 (+)
CAST/EiJ	MGP_CASTEiJ_G0028295	protein coding gene	Chr4:151873586-151882002 (+)
CBA/J	MGP_CBAJ_G0028844	protein coding gene	Chr4:166883961-166892290 (+)
DBA/2J	MGP_DBA2J_G0028993	protein coding gene	Chr4:149936815-149945144 (+)
FVB/NJ	MGP_FVBNJ_G0028957	protein coding gene	Chr4:149099015-149107344 (+)
LP/J	MGP_LPJ_G0029083	protein coding gene	Chr4:156365967-156374296 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028984	protein coding gene	Chr4:169893287-169902252 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029642	protein coding gene	Chr4:154493886-154502215 (+)
PWK/PhJ	MGP_PWKPhJ_G0028015	protein coding gene	Chr4:146004546-146012960 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027849	protein coding gene	Chr4:148780880-148790687 (+)
WSB/EiJ	MGP_WSBEiJ_G0028375	protein coding gene	Chr4:154681720-154691930 (+)

Human Ortholog

RPL22, ribosomal protein L22

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL22, ribosomal protein L22
Synonyms

EAP, eL22, HBP15, HBP15/L22, L22
Links

HGNC:10315

NCBI Gene ID: 6146

neXtProt AC: NX_P35268

UniProt: P35268
Chr Location

1p36.31; chr1:6185020-6209389 (-) GRCh38

MGI Vertebrate Homology

Rpl22 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL22
Gene Tree

Rpl22

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Phenotype Summary

14 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
245 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

122
Endonuclease-mediated

4
Gene trapped

112
Targeted

6
Genomic Mutations

3 involving Rpl22
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit arrested alpha beta lineage T cell differentiation at the beta selection stage.

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl22

ZFIN rpl22

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All Sequences

65
RefSeq

8
UniProt

2
CCDS

CCDS18999.1

Ensembl

ENSMUSG00000028936 (Evidence)
NCBI Gene

19934

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028936	Ensembl Gene Model \| MGI Sequence Detail	8330	C57BL/6J	± kb
transcript	ENSMUST00000139685	Ensembl \| MGI Sequence Detail	2051	Not Applicable
polypeptide	ENSMUSP00000118787	Ensembl \| MGI Sequence Detail	128	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014201 large ribosomal subunit protein eL22

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR002671 Large ribosomal subunit protein eL22

IPR038526 Large ribosomal subunit protein eL22 superfamily
GlyGen

P67984 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 5

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MGD-MRK-16021, MGI:1914433

Summaries

All 278

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 245
Earliest

J:17186 Fujita Y, et al., A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem Biophys Res Commun. 1994 Mar 15;199(2):706-13
Latest

J:354981 Loganathan S, et al., Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice. Transl Psychiatry. 2024 Oct 6;14(1):421

TSS for Rpl22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40547	Chr4:152410288-152410333 (+)	112 bp
Tssr40548	Chr4:152414510-152414529 (+)	4,321 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24