Mc5r MGI Mouse Gene Detail - MGI:99420 - melanocortin 5 receptor

Symbol

Mc5r
Name

melanocortin 5 receptor

Feature Type

protein coding gene
IDs

MGI:99420
NCBI Gene: 17203
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr18:68470575-68475517 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 41.46 cM
Mapping Data

2 experiments

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99420	protein coding gene	Chr18:68469811-68475517 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024535	protein coding gene	Chr18:68686352-68688460 (+)
A/J	MGP_AJ_G0024502	protein coding gene	Chr18:65709187-65711295 (+)
AKR/J	MGP_AKRJ_G0024473	protein coding gene	Chr18:67620678-67622786 (+)
BALB/cJ	MGP_BALBcJ_G0024502	protein coding gene	Chr18:65869102-65871210 (+)
C3H/HeJ	MGP_C3HHeJ_G0024270	protein coding gene	Chr18:67762884-67764992 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024948	protein coding gene	Chr18:70493916-70496024 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022379	protein coding gene	Chr18:65057370-65059486 (+)
CAST/EiJ	MGP_CASTEiJ_G0023743	protein coding gene	Chr18:67798922-67801031 (+)
CBA/J	MGP_CBAJ_G0024239	protein coding gene	Chr18:72905171-72907279 (+)
DBA/2J	MGP_DBA2J_G0024369	protein coding gene	Chr18:65323640-65325748 (+)
FVB/NJ	MGP_FVBNJ_G0024335	protein coding gene	Chr18:64701129-64703237 (+)
LP/J	MGP_LPJ_G0024453	protein coding gene	Chr18:68542369-68544477 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024365	protein coding gene	Chr18:74172907-74175015 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024996	protein coding gene	Chr18:67793600-67795708 (+)
PWK/PhJ	MGP_PWKPhJ_G0023487	protein coding gene	Chr18:65647508-65649616 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023291	protein coding gene	Chr18:67943591-67945693 (+)
WSB/EiJ	MGP_WSBEiJ_G0023806	protein coding gene	Chr18:67699399-67701507 (+)

Human Ortholog

MC5R, melanocortin 5 receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MC5R, melanocortin 5 receptor
Synonyms

MC2
Links

HGNC:6933

NCBI Gene ID: 4161

neXtProt AC: NX_P33032

UniProt: P33032
Chr Location

18p11.21; chr18:13824149-13827323 (+) GRCh38

MGI Vertebrate Homology

Mc5r stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MC5R
Gene Tree

Mc5r

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Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids. Males exhibit less aggressive and more defensive behavior when placed with wildtype males.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mc5r

ZFIN mc5ra, mc5rb

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All Sequences

36
RefSeq

3
UniProt

3
CCDS

CCDS29327.1

Ensembl

ENSMUSG00000007480 (Evidence)
NCBI Gene

17203

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007480	Ensembl Gene Model \| MGI Sequence Detail	4943	C57BL/6J	± kb
transcript	ENSMUST00000172148	Ensembl \| MGI Sequence Detail	3996	Not Applicable
polypeptide	ENSMUSP00000130497	Ensembl \| MGI Sequence Detail	325	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001238 melanocortin receptor 5

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000621 Melanocortin 5 receptor

IPR001671 Melanocortin/ACTH receptor

IPR001908 Melanocortin receptor 3-5
GlyGen

P41149 4 sites

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All nucleic 14

Genomic 4

cDNA 9

Primer pair 1

Microarray probesets 3

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MGD-MRK-16182

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 15
Earliest

J:17828 Labbe O, et al., Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry. 1994 Apr 19;33(15):4543-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mc5r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151786	Chr18:68470575-68470588 (+)	7 bp
Tssr151787	Chr18:68470616-68470617 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24