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Etv4 Gene Detail
Summary
  • Symbol
    Etv4
  • Name
    ets variant 4
  • Synonyms
    Pea-3, Pea3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99423
    NCBI Gene: 18612
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101660568-101676197 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99423
 protein coding gene Chr11:101660568-101677963 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019212
 protein coding gene Chr11:104692077-104708633 (-)
A/J MGP_AJ_G0019180
 protein coding gene Chr11:100278346-100294292 (-)
AKR/J MGP_AKRJ_G0019149
 protein coding gene Chr11:103391681-103407315 (-)
BALB/cJ MGP_BALBcJ_G0019154
 protein coding gene Chr11:100760608-100776220 (-)
C3H/HeJ MGP_C3HHeJ_G0018963
 protein coding gene Chr11:103583238-103599936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019603
 protein coding gene Chr11:107960060-107977655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017229
 protein coding gene Chr11:97698506-97714058 (-)
CAST/EiJ MGP_CASTEiJ_G0018517
 protein coding gene Chr11:104533144-104550593 (-)
CBA/J MGP_CBAJ_G0018932
 protein coding gene Chr11:112395964-112414209 (-)
DBA/2J MGP_DBA2J_G0019044
 protein coding gene Chr11:99799029-99814837 (-)
FVB/NJ MGP_FVBNJ_G0019034
 protein coding gene Chr11:99327818-99343407 (-)
LP/J MGP_LPJ_G0019113
 protein coding gene Chr11:105211834-105229886 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019065
 protein coding gene Chr11:111952648-111971055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019641
 protein coding gene Chr11:103730745-103749860 (-)
PWK/PhJ MGP_PWKPhJ_G0018280
 protein coding gene Chr11:100850535-100866701 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018072
 protein coding gene Chr11:103466526-103483039 (-)
WSB/EiJ MGP_WSBEiJ_G0018566
 protein coding gene Chr11:103720608-103739551 (-)



Homology
more
  • Human Ortholog
    ETV4, ETS variant transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ETV4, ETS variant transcription factor 4
  • Synonyms
    E1A-F, E1AF, PEA3, PEAS3
  • Links
    NCBI Gene ID: 2118
    neXtProt AC: NX_P43268
    UniProt: P43268

  • Chr Location
    17q21.31; chr17:43527844-43579620 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    25 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit male infertility due to failure to ejaculate, impaired branching of motor neurons, and abnormal mammary gland terminal differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1169
  • Tissues
    294
  • cDNA Data
    50
  • Literature Summary
    214
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017724 Ensembl Gene Model | MGI Sequence Detail 15630 C57BL/6J ±  kb
    transcript ENSMUST00000017868 Ensembl | MGI Sequence Detail 2395 Not Applicable  
    polypeptide ENSMUSP00000017868 Ensembl | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 2
      cDNA 52
      Primer pair 8
      Other 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13225, MGD-MRK-16186, MGI:2144527
    References
    more
    • Summaries
      All 293
      Developmental Gene Expression 214
      Diseases 1
      Gene Ontology 13
      Phenotypes 46
    • Earliest
      J:588 Martin ME, et al., Expression of a 91-kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells. Mol Cell Biol. 1992 May;12(5):2213-21
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory