Arf4 MGI Mouse Gene Detail - MGI:99433

Symbol

Arf4
Name

ARF GTPase 4

Feature Type

protein coding gene
IDs

MGI:99433
NCBI Gene: 11843
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr14:26359289-26377997 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 16.09 cM
Mapping Data

4 experiments

SNPs within 2kb

499 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99433	protein coding gene	Chr14:26359229-26386239 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021083	protein coding gene	Chr14:19620341-19647196 (+)
A/J	MGP_AJ_G0021032	protein coding gene	Chr14:18842706-18869177 (+)
AKR/J	MGP_AKRJ_G0021009	protein coding gene	Chr14:19876507-19903317 (+)
BALB/cJ	MGP_BALBcJ_G0021035	protein coding gene	Chr14:18957632-18986006 (+)
C3H/HeJ	MGP_C3HHeJ_G0020819	protein coding gene	Chr14:19737642-19767703 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021468	protein coding gene	Chr14:20440952-20468409 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019031	protein coding gene	Chr14:19003104-19028893 (+)
CAST/EiJ	MGP_CASTEiJ_G0020343	protein coding gene	Chr14:19344550-19373814 (+)
CBA/J	MGP_CBAJ_G0020785	protein coding gene	Chr14:21251817-21284961 (+)
DBA/2J	MGP_DBA2J_G0020908	protein coding gene	Chr14:18928160-18955245 (+)
FVB/NJ	MGP_FVBNJ_G0020891	protein coding gene	Chr14:18891912-18918390 (+)
LP/J	MGP_LPJ_G0020976	protein coding gene	Chr14:19885250-19913996 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020917	protein coding gene	Chr14:20587099-20614607 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021501	protein coding gene	Chr14:19637427-19672844 (+)
PWK/PhJ	MGP_PWKPhJ_G0020092	protein coding gene	Chr14:18301874-18329860 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019915	protein coding gene	Chr14:19115861-19144335 (+)
WSB/EiJ	MGP_WSBEiJ_G0020399	protein coding gene	Chr14:19682738-19710878 (+)

Human Ortholog

ARF4, ARF GTPase 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARF4, ARF GTPase 4
Synonyms

ARF2
Links

HGNC:655

NCBI Gene ID: 378

neXtProt AC: NX_P18085

UniProt: P18085
Chr Location

3p14.3; chr3:57571363-57598220 (-) GRCh38

MGI Vertebrate Homology

Arf4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARF4
Gene Tree

Arf4

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Phenotype Summary

17 phenotypes from 4 alleles in 4 genetic backgrounds
7 phenotypes from multigenic genotypes
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

2
Gene trapped

11
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit embryonic lethality. Mice heterozygous for the gene trap allele exhibit failure to increase exploration of an object in a novel context, reduced spine density and reduced mESPC amplitudes.

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All GO Annotations

53
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

994
Tissues

106
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arf4

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All Sequences

60
RefSeq

2
UniProt

6
CCDS

CCDS26881.1

Ensembl

ENSMUSG00000021877 (Evidence)
NCBI Gene

11843

			Length	Strain/Species	Flank
genomic	11843	NCBI Gene Model \| MGI Sequence Detail	18709	C57BL/6J	± kb
transcript	NM_007479	RefSeq \| MGI Sequence Detail	1689	C57BL/6
polypeptide	P61750	UniProt \| EBI \| MGI Sequence Detail	180	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004203 ADP-ribosylation factor 4

(term hierarchy)
InterPro Domains

IPR045872 ADP-ribosylation factor 1-5

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain
GlyGen

P61750 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 6

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MGD-MRK-16197, MGI:1353617

Summaries

All 55

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 16
Earliest

J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124688	Chr14:26359167-26359179 (+)	-116 bp
Tssr124689	Chr14:26359191-26359202 (+)	-92 bp
Tssr124690	Chr14:26359275-26359306 (+)	2 bp
Tssr124691	Chr14:26359312-26359379 (+)	57 bp
Tssr124692	Chr14:26359392-26359404 (+)	109 bp
Tssr124693	Chr14:26366744-26366748 (+)	7,457 bp
Tssr124694	Chr14:26367861-26367870 (+)	8,577 bp
Tssr124695	Chr14:26370401-26370404 (+)	11,114 bp
Tssr124696	Chr14:26373391-26373396 (+)	14,105 bp
Tssr124697	Chr14:26377041-26377119 (+)	17,791 bp
Tssr124698	Chr14:26377139-26377152 (+)	17,857 bp
Tssr124699	Chr14:26377156-26377195 (+)	17,887 bp
Tssr124700	Chr14:26377237-26377254 (+)	17,957 bp
Tssr124701	Chr14:26377258-26377271 (+)	17,976 bp
Tssr124702	Chr14:26377325-26377340 (+)	18,044 bp
Tssr124703	Chr14:26377639-26377658 (+)	18,360 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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