About   Help   FAQ
Mtpn Gene Detail
Summary
  • Symbol
    Mtpn
  • Name
    myotrophin
  • Synonyms
    5033418D15Rik, Gcdp, V1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99445
    NCBI Gene: 14489
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:35485841-35516823 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.27 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    646 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99445
 protein coding gene Chr6:35485759-35516823 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030572
 protein coding gene Chr6:33635933-33673158 (-)
A/J MGP_AJ_G0030545
 protein coding gene Chr6:32163223-32193761 (-)
AKR/J MGP_AKRJ_G0030472
 protein coding gene Chr6:33253802-33286186 (-)
BALB/cJ MGP_BALBcJ_G0030555
 protein coding gene Chr6:32367919-32399109 (-)
C3H/HeJ MGP_C3HHeJ_G0030268
 protein coding gene Chr6:33234152-33266374 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031009
 protein coding gene Chr6:34479797-34519270 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028221
 protein coding gene Chr6:30246767-30279224 (-)
CAST/EiJ MGP_CASTEiJ_G0029670
 protein coding gene Chr6:33056378-33089300 (-)
CBA/J MGP_CBAJ_G0030246
 protein coding gene Chr6:35828713-35864147 (-)
DBA/2J MGP_DBA2J_G0030390
 protein coding gene Chr6:32045992-32087174 (-)
FVB/NJ MGP_FVBNJ_G0030344
 protein coding gene Chr6:31860660-31891346 (-)
LP/J MGP_LPJ_G0030477
 protein coding gene Chr6:33734885-33767821 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030380
 protein coding gene Chr6:38115607-38161840 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031039
 protein coding gene Chr6:33151011-33191905 (-)
PWK/PhJ MGP_PWKPhJ_G0029384
 protein coding gene Chr6:31684286-31715867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029220
 protein coding gene Chr6:32835809-32873060 (-)
WSB/EiJ MGP_WSBEiJ_G0029746
 protein coding gene Chr6:33092404-33131091 (-)



Homology
more
  • Human Ortholog
    MTPN, myotrophin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
Human Diseases
more
  • Diseases
    2 with Mtpn mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    107
  • cDNA Data
    344
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029840 Ensembl Gene Model | MGI Sequence Detail 30983 C57BL/6J ±  kb
    transcript ENSMUST00000031866 Ensembl | MGI Sequence Detail 3960 Not Applicable  
    polypeptide ENSMUSP00000031866 Ensembl | MGI Sequence Detail 118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 348
      cDNA 346
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16213, MGI:2441694
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:17519 Taoka M, et al., Murine cerebellar neurons express a novel gene encoding a protein related to cell cycle control and cell fate determination proteins. J Biol Chem. 1994 Apr 1;269(13):9946-51
    • Latest
      J:239317 Bourke LM, et al., Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Differentiation. 2017 Mar - Apr;94:8-20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory