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Ifit2 Gene Detail
Summary
  • Symbol
    Ifit2
  • Name
    interferon-induced protein with tetratricopeptide repeats 2
  • Synonyms
    Ifi54
  • Feature Type
    protein coding gene
  • IDs
    MGI:99449
    NCBI Gene: 15958
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34528094-34553819 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 29.73 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99449
 protein coding gene Chr19:34527961-34553934 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025059
 protein coding gene Chr19:33287225-33318395 (+)
A/J MGP_AJ_G0025037
 protein coding gene Chr19:31679073-31704890 (+)
AKR/J MGP_AKRJ_G0025003
 protein coding gene Chr19:32754428-32781504 (+)
BALB/cJ MGP_BALBcJ_G0025033
 protein coding gene Chr19:31793136-31819276 (+)
C3H/HeJ MGP_C3HHeJ_G0024792
 protein coding gene Chr19:32853803-32879687 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025474
 protein coding gene Chr19:34249436-34281932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022892
 protein coding gene Chr19:31118046-31141500 (+)
CAST/EiJ MGP_CASTEiJ_G0024262
 protein coding gene Chr19:32604274-32634756 (+)
CBA/J MGP_CBAJ_G0024769
 protein coding gene Chr19:35867364-35900362 (+)
DBA/2J MGP_DBA2J_G0024901
 protein coding gene Chr19:31582325-31608948 (+)
FVB/NJ MGP_FVBNJ_G0024862
 protein coding gene Chr19:31420713-31446525 (+)
LP/J MGP_LPJ_G0024987
 protein coding gene Chr19:33374128-33404103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024893
 protein coding gene Chr19:35642986-35672783 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025532
 protein coding gene Chr19:32855803-32883605 (+)
PWK/PhJ MGP_PWKPhJ_G0024011
 protein coding gene Chr19:31389079-31415043 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023812
 protein coding gene Chr19:31711244-31740378 (+)
WSB/EiJ MGP_WSBEiJ_G0024326
 protein coding gene Chr19:32929796-32957472 (+)



Homology
more
  • Human Ortholog
    IFIT2, interferon induced protein with tetratricopeptide repeats 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFIT2, interferon induced protein with tetratricopeptide repeats 2
  • Synonyms
    cig42, G10P2, GARG-39, IFI-54, IFI54, IFI-54K, IFIT-2, ISG-54, ISG54, ISG-54 K, ISG-54K, P54
  • Links
    NCBI Gene ID: 3433
    neXtProt AC: NX_P09913
    UniProt: P09913

  • Chr Location
    10q23.31; chr10:89283694-89309271 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susuceptibility to VSV infection with increased lethality and brain viral titer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    102
  • cDNA Data
    10
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045932 Ensembl Gene Model | MGI Sequence Detail 25726 C57BL/6J ±  kb
    transcript ENSMUST00000102826 Ensembl | MGI Sequence Detail 3818 Not Applicable  
    polypeptide ENSMUSP00000099890 Ensembl | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029551 interferon-induced protein with tetratricopeptide repeats 2
      (term hierarchy)
    • InterPro Domains
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 10
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16218, MGI:2147678
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:18633 Lee CG, et al., Molecular cloning and characterization of a murine LPS-inducible cDNA. J Immunol. 1994 Jun 15;152(12):5758-67
    • Latest
      J:346630 Zhang X, et al., Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory