Arrb2 MGI Mouse Gene Detail - MGI:99474

Symbol

Arrb2
Name

arrestin, beta 2
Synonyms

Arr3, arrestin 3, beta arr2, beta-arrestin-2, beta-arrestin2

Feature Type

protein coding gene
IDs

MGI:99474
NCBI Gene: 216869
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:70323461-70331654 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

3 experiments

SNPs within 2kb

118 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99474	protein coding gene	Chr11:70323051-70331654 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018594	protein coding gene	Chr11:70965915-70974109 (+)
A/J	MGP_AJ_G0018562	protein coding gene	Chr11:68271816-68280009 (+)
AKR/J	MGP_AKRJ_G0018531	protein coding gene	Chr11:70321347-70329539 (+)
BALB/cJ	MGP_BALBcJ_G0018534	protein coding gene	Chr11:68591280-68599474 (+)
C3H/HeJ	MGP_C3HHeJ_G0018347	protein coding gene	Chr11:70343386-70351580 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018985	protein coding gene	Chr11:73104966-73113159 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016630	protein coding gene	Chr11:65198979-65207196 (+)
CAST/EiJ	MGP_CASTEiJ_G0017902	protein coding gene	Chr11:70599254-70607454 (+)
CBA/J	MGP_CBAJ_G0018319	protein coding gene	Chr11:76380121-76388315 (+)
DBA/2J	MGP_DBA2J_G0018429	protein coding gene	Chr11:67856436-67864619 (+)
FVB/NJ	MGP_FVBNJ_G0018419	protein coding gene	Chr11:67499841-67508024 (+)
LP/J	MGP_LPJ_G0018499	protein coding gene	Chr11:71536541-71544735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018442	protein coding gene	Chr11:76965423-76973617 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019027	protein coding gene	Chr11:70584328-70592522 (+)
PWK/PhJ	MGP_PWKPhJ_G0017676	protein coding gene	Chr11:68494782-68502956 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017466	protein coding gene	Chr11:70391432-70399605 (+)
WSB/EiJ	MGP_WSBEiJ_G0017956	protein coding gene	Chr11:70245154-70253328 (+)

Human Ortholog

ARRB2, arrestin beta 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARRB2, arrestin beta 2
Synonyms

ARB2, ARR2, BARR2
Links

HGNC:712

NCBI Gene ID: 409

neXtProt AC: NX_P32121

UniProt: P32121
Chr Location

17p13.2; chr17:4710596-4721499 (+) GRCh38

MGI Vertebrate Homology

Arrb2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARRB2
Gene Tree

Arrb2

Diseases

4 with human ARRB2 associations

				Human Disease	Mouse Models
				glioblastoma IDs glioblastoma DOID:3068 DOID:3075 DOID:3080 MESH:D005909 NCI:C129295 NCI:C39750 NCI:C9094 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422
				heroin dependence IDs heroin dependence DOID:9976 MESH:D006556 NCI:C34694 UMLS_CUI:C0019337
				nicotine dependence IDs nicotine dependence DOID:0050742 EFO:0003768 ICD10CM:F17 MESH:D014029 NCI:C54203 UMLS_CUI:C0028043
				opiate dependence IDs opiate dependence DOID:2559 ICD10CM:F11.2 ICD9CM_2006:304.0 ICD9CM:304.0 ICD9CM:304.00 MESH:D009293 UMLS_CUI:C0524662

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotypes from multigenic genotypes
175 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

10
Genomic Mutations

2 involving Arrb2
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit enhanced morphine analgesia, an enhanced inflammatory response and reduced threshold to lethal endotoxin challenge, and impaired T and B lymphocyte chemotaxis.

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All GO Annotations

119
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

37
cDNA Data

45
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arrb2

ZFIN arrb2a, arrb2b

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All Sequences

75
RefSeq

14
UniProt

9
CCDS

CCDS24946.1, CCDS70226.1

Ensembl

ENSMUSG00000060216 (Evidence)
NCBI Gene

216869

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060216	Ensembl Gene Model \| MGI Sequence Detail	8194	C57BL/6J	± kb
transcript	ENSMUST00000108568	Ensembl \| MGI Sequence Detail	1777	Not Applicable
polypeptide	ENSMUSP00000104208	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000004320 beta-arrestin-2

(term hierarchy)
InterPro Domains

IPR000698 Arrestin

IPR017864 Arrestin, conserved site

IPR011022 Arrestin C-terminal-like domain

IPR014752 Arrestin-like, C-terminal

IPR011021 Arrestin-like, N-terminal

IPR014753 Arrestin, N-terminal

IPR014756 Immunoglobulin E-set

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All nucleic 47

cDNA 47

Microarray probesets 4

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MGD-MRK-16248, MGI:2144136, MGI:2144500

Summaries

All 254

Developmental Gene Expression 9

Gene Ontology 17

Phenotypes 175
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:349923 George K, et al., Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons. iScience. 2024 Jun 21;27(6):110047

TSS for Arrb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102676	Chr11:70323378-70323383 (+)	-80 bp
Tssr102677	Chr11:70323398-70323416 (+)	-54 bp
Tssr102678	Chr11:70323427-70323450 (+)	-22 bp
Tssr102679	Chr11:70323453-70323533 (+)	32 bp
Tssr3568	Chr11:70324794-70324808 (+)	1,340 bp
Tssr102680	Chr11:70326532-70326543 (+)	3,077 bp
Tssr102681	Chr11:70326975-70326996 (+)	3,525 bp
Tssr102682	Chr11:70327001-70327019 (+)	3,549 bp
Tssr102691	Chr11:70329503-70329521 (+)	6,051 bp
Tssr102692	Chr11:70331140-70331164 (+)	7,691 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24