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Cebpa Gene Detail
Summary
  • Symbol
    Cebpa
  • Name
    CCAAT/enhancer binding protein alpha
  • Synonyms
    Cebp, C/ebpalpha, C/EBP alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99480
    NCBI Gene: 12606
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:34818718-34821353 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 21.02 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99480
 protein coding gene Chr7:34818718-34821353 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032082
 protein coding gene Chr7:34473950-34476582 (+)
A/J MGP_AJ_G0032062
 protein coding gene Chr7:33572406-33575040 (+)
AKR/J MGP_AKRJ_G0031995
 protein coding gene Chr7:34368277-34370911 (+)
BALB/cJ MGP_BALBcJ_G0032069
 protein coding gene Chr7:33862811-33865443 (+)
C3H/HeJ MGP_C3HHeJ_G0031786
 protein coding gene Chr7:35268670-35271305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032546
 protein coding gene Chr7:36180150-36182785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029579
 protein coding gene Chr7:34290152-34292776 (+)
CAST/EiJ MGP_CASTEiJ_G0031121
 protein coding gene Chr7:26413792-26416431 (+)
CBA/J MGP_CBAJ_G0031754
 protein coding gene Chr7:37314700-37319927 (+)
DBA/2J MGP_DBA2J_G0031906
 protein coding gene Chr7:33410570-33413203 (+)
FVB/NJ MGP_FVBNJ_G0031861
 protein coding gene Chr7:33344757-33347391 (+)
LP/J MGP_LPJ_G0031983
 protein coding gene Chr7:34809886-34812558 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031899
 protein coding gene Chr7:36336288-36338922 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032561
 protein coding gene Chr7:33912021-33914658 (+)
PWK/PhJ MGP_PWKPhJ_G0030843
 protein coding gene Chr7:26742612-26745357 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030678
 protein coding gene Chr7:23493590-23496227 (+)
WSB/EiJ MGP_WSBEiJ_G0031231
 protein coding gene Chr7:34463316-34465948 (+)



Homology
more
  • Human Ortholog
    CEBPA, CCAAT enhancer binding protein alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEBPA, CCAAT enhancer binding protein alpha
  • Synonyms
    CEBP, C/EBP-alpha
  • Links
    NCBI Gene ID: 1050
    neXtProt AC: NX_P49715
    UniProt: P49715

  • Chr Location
    19q13.11; chr19:33299934-33302534 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cebpa mouse models; 1 with human CEBPA associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    109 phenotypes from 17 alleles in 18 genetic backgrounds
    57 phenotypes from multigenic genotypes
    2 images
    131 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defects of the liver, neutrophils, lung, and brown fat, resulting in impaired glycogen storage and lipid accumulation, hypoglycemia, reduced uncoupling protein, and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    136
  • GO References
    59
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1141
  • Tissues
    172
  • cDNA Data
    106
  • Literature Summary
    112
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12606 NCBI Gene Model | MGI Sequence Detail 2636 C57BL/6J ±  kb
    transcript NM_001287515 RefSeq | MGI Sequence Detail 2636 ZRU/MplStud  
    polypeptide P53566 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 1
      cDNA 115
      Primer pair 18
      Other 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16254, MGD-MRK-1916
    References
    more
    • Summaries
      All 417
      Developmental Gene Expression 112
      Diseases 1
      Gene Ontology 59
      Phenotypes 131
    • Earliest
      J:9999 Xanthopoulos KG, et al., The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenet Cell Genet. 1989;50(2-3):174-5
    • Latest
      J:359043 Tan Q, et al., Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis. JCI Insight. 2024 Jul 16;9(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory