Fgb MGI Mouse Gene Detail - MGI:99501

Symbol

Fgb
Name

fibrinogen beta chain
Synonyms

2510049G14Rik

Feature Type

protein coding gene
IDs

MGI:99501
NCBI Gene: 110135
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr3:82949553-82957170 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 36.98 cM
Mapping Data

3 experiments

SNPs within 2kb

307 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99501	protein coding gene	Chr3:82947448-82957170 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027333	protein coding gene	Chr3:82863419-82873184 (-)
A/J	MGP_AJ_G0027297	protein coding gene	Chr3:80133709-80143484 (-)
AKR/J	MGP_AKRJ_G0027263	protein coding gene	Chr3:82039392-82049165 (-)
BALB/cJ	MGP_BALBcJ_G0027306	protein coding gene	Chr3:80225268-80235043 (-)
C3H/HeJ	MGP_C3HHeJ_G0027050	protein coding gene	Chr3:82325478-82335253 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027752	protein coding gene	Chr3:85981722-85991444 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025105	protein coding gene	Chr3:75852667-75862416 (-)
CAST/EiJ	MGP_CASTEiJ_G0026497	protein coding gene	Chr3:82510582-82520358 (-)
CBA/J	MGP_CBAJ_G0027025	protein coding gene	Chr3:88888106-88897881 (-)
DBA/2J	MGP_DBA2J_G0027161	protein coding gene	Chr3:79676594-79686373 (-)
FVB/NJ	MGP_FVBNJ_G0027129	protein coding gene	Chr3:77958295-77968013 (-)
LP/J	MGP_LPJ_G0027269	protein coding gene	Chr3:83850891-83860661 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027148	protein coding gene	Chr3:95282510-95292228 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027810	protein coding gene	Chr3:81836127-81845848 (-)
PWK/PhJ	MGP_PWKPhJ_G0026231	protein coding gene	Chr3:79437734-79447516 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026047	protein coding gene	Chr3:81025585-81035327 (-)
WSB/EiJ	MGP_WSBEiJ_G0026575	protein coding gene	Chr3:82169462-82179243 (-)

Human Ortholog

FGB, fibrinogen beta chain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGB, fibrinogen beta chain
Synonyms

HEL-S-78p
Links

HGNC:3662

NCBI Gene ID: 2244

neXtProt AC: NX_P02675

UniProt: P02675
Chr Location

4q31.3; chr4:154562980-154572807 (+) GRCh38

MGI Vertebrate Homology

Fgb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGB
Gene Tree

Fgb

Diseases

7 with human FGB associations

				Human Disease	Mouse Models
				cardiovascular system disease IDs cardiovascular system disease DOID:1287 DOID:73 ICD9CM:429.2 MESH:D002318 NCI:C2931 UMLS_CUI:C0007222
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
				congenital afibrinogenemia IDs congenital afibrinogenemia DOID:2236 MESH:D000347 NCI:C98130 OMIM:202400 UMLS_CUI:C0001733
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				end stage renal disease IDs end stage renal disease DOID:783
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				thrombosis IDs thrombosis DOID:0060903 MESH:D013927

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

2
Transgenic

2
Genomic Mutations

2 involving Fgb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

67
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

35
cDNA Data

246
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FGB

Xenbase fgb

ZFIN fgb

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS17432.1

Ensembl

ENSMUSG00000033831 (Evidence)
NCBI Gene

110135

			Length	Strain/Species	Flank
genomic	110135	NCBI Gene Model \| MGI Sequence Detail	7618	C57BL/6J	± kb
transcript	NM_181849	RefSeq \| MGI Sequence Detail	1713	ZRU/MplStud
polypeptide	Q8K0E8	UniProt \| EBI \| MGI Sequence Detail	481	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007472 fibrinogen beta chain

(term hierarchy)
InterPro Domains

IPR037579 Fibrinogen

IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

IPR020837 Fibrinogen, conserved site

IPR036056 Fibrinogen-like, C-terminal
GlyGen

Q8K0E8 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 248

cDNA 246

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-16277, MGI:1915158

Summaries

All 66

Developmental Gene Expression 16

Diseases 1

Gene Ontology 9

Phenotypes 18
Earliest

J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fgb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33826	Chr3:82957104-82957124 (-)	56 bp
Tssr33825	Chr3:82956421-82956436 (-)	741 bp
Tssr33824	Chr3:82954126-82954153 (-)	3,030 bp
Tssr33823	Chr3:82954104-82954115 (-)	3,060 bp
Tssr33822	Chr3:82954085-82954099 (-)	3,078 bp
Tssr33821	Chr3:82954047-82954065 (-)	3,114 bp
Tssr33820	Chr3:82954029-82954046 (-)	3,132 bp
Tssr33819	Chr3:82953993-82954021 (-)	3,163 bp
Tssr33818	Chr3:82953982-82953990 (-)	3,184 bp
Tssr33817	Chr3:82953460-82953496 (-)	3,692 bp
Tssr33816	Chr3:82953412-82953450 (-)	3,739 bp
Tssr33815	Chr3:82953382-82953388 (-)	3,785 bp
Tssr33814	Chr3:82953277-82953280 (-)	3,891 bp
Tssr33813	Chr3:82952312-82952366 (-)	4,831 bp
Tssr33812	Chr3:82952303-82952308 (-)	4,864 bp
Tssr33811	Chr3:82952219-82952273 (-)	4,924 bp
Tssr33810	Chr3:82951554-82951620 (-)	5,583 bp
Tssr33809	Chr3:82951189-82951216 (-)	5,967 bp
Tssr33808	Chr3:82951173-82951184 (-)	5,991 bp
Tssr33807	Chr3:82951102-82951112 (-)	6,063 bp
Tssr33806	Chr3:82950767-82950784 (-)	6,394 bp
Tssr33805	Chr3:82950703-82950714 (-)	6,461 bp
Tssr33804	Chr3:82949762-82949775 (-)	7,401 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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