Szf1 QTL Detail

Summary

• Symbol
  Szf1
• Name
  seizure frequency 1

• Feature Type
  QTL
• IDs
  MGI:99539
  NCBI Gene: 109749

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

Tonic-clonic and generalized seizures resembling common human epilepsies occur in SWXL4/Ty. Susceptibility alleles inherited from SWR/J and C57L/J parental strains of SWXL4/Ty account for the seizures in this strain. Szf1 accounts for 32% of genetic variance in an (SWL4/Ty x ABP/Le)F2 cross.

Sequences &
Gene Models

• NCBI Gene
  109749

Other
Accession IDs

MGD-MRK-16317

References

• Summaries
  All 4
• Earliest
  J:19719 Frankel WN, et al., Genetic epilepsy model derived from common inbred mouse strains. Genetics. 1994 Oct;138(2):481-9
• Latest
  J:66159 Legare ME, et al., Multiple seizure susceptibility genes on chromosome 7 in SWXL-4 congenic mouse strains. Genomics. 2000 Nov 15;70(1):62-5