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Slx Gene Detail
Summary
  • Symbol
    Slx
  • Name
    Sycp3 like X-linked
  • Synonyms
    EG664958, Xmr
  • Feature Type
    protein coding gene
  • IDs
    MGI:99543
    NCBI Gene: 664829
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:26477957-26500865 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 18.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99543
 protein coding gene ChrX:26477956-26500865 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
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  • Gene Tree
    Slx
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    2 phenotype references
Mice homozygous for a null allele exhibit normal male reproductive morphology and physiology. Mice homozygous for a null allele of Slx and Slxl1 exhibit defective spermiogenesis and male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    17
  • cDNA Data
    2
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 664829 NCBI Gene Model | MGI Sequence Detail 22909 C57BL/6J ±  kb
transcript NM_001136476 RefSeq | MGI Sequence Detail 924 Not Specified  
polypeptide NP_001129948 RefSeq | MGI Sequence Detail 212 Not Specified  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR051443 X-linked Lymphocyte-regulated/Synaptonemal Complex Protein 3
    IPR006888 XLR/SYCP3/FAM9 domain
Molecular
Reagents
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  • All nucleic 8
    cDNA 2
    Primer pair 6
Other
Accession IDs
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MGD-MRK-16321, MGI:3644733
References
more
  • Summaries
    All 23
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:17470 Calenda A, et al., The meiosis-specific Xmr gene product is homologous to the lymphocyte Xlr protein and is a component of the XY body. EMBO J. 1994 Jan 1;13(1):100-9
  • Latest
    J:304511 Kruger AN, et al., A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice. Curr Biol. 2019 Nov 4;29(21):3699-3706.e5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory