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Iglc1 Gene Detail
Summary
  • Symbol
    Iglc1
  • Name
    immunoglobulin lambda constant 1
  • Synonyms
    Clambda1
  • Feature Type
    gene segment
  • IDs
    MGI:99546
    NCBI Gene: 110785
  • Alliance
    gene page
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr16:18880502-18880821 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.80 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99546
 gene segment Chr16:18880368-18880821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000011
 gene segment Chr16:16333918-16334371 (-)
A/J MGP_AJ_G0000011
 gene segment Chr16:15528689-15529142 (-)
AKR/J MGP_AKRJ_G0000010
 gene segment Chr16:16149575-16150028 (-)
BALB/cJ MGP_BALBcJ_G0000011
 gene segment Chr16:15678588-15679041 (-)
C3H/HeJ MGP_C3HHeJ_G0000011
 gene segment Chr16:16306458-16306911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000011
 gene segment Chr16:16649417-16649870 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000010
 gene segment Chr16:15550393-15550846 (-)
CAST/EiJ MGP_CASTEiJ_G0000012
 gene segment Chr16:16378408-16378861 (-)
CBA/J MGP_CBAJ_G0000011
 gene segment Chr16:17352302-17352755 (-)
DBA/2J MGP_DBA2J_G0000011
 gene segment Chr16:15426969-15427422 (-)
FVB/NJ MGP_FVBNJ_G0000011
 gene segment Chr16:15499299-15499752 (-)
LP/J MGP_LPJ_G0000011
 gene segment Chr16:16082518-16082971 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000010
 gene segment Chr16:16970684-16971137 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000011
 gene segment Chr16:16072880-16073333 (-)
PWK/PhJ MGP_PWKPhJ_G0000011
 gene segment Chr16:15721995-15722448 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000010
 gene segment Chr16:16088046-16088493 (-)
WSB/EiJ MGP_WSBEiJ_G0000011
 gene segment Chr16:16093810-16094263 (-)



Homology
more
  • Human Ortholog
    IGLC2, immunoglobulin lambda constant 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGLC2, immunoglobulin lambda constant 2
  • Synonyms
    IGLC
  • Links
    NCBI Gene ID: 3538
    UniProt: P0DOY2

  • Chr Location
    22q11.22; chr22:22900976-22901437 (+)  GRCh38
  • Human Ortholog
    IGLC3, immunoglobulin lambda constant 3 (Kern-Oz+ marker)
  • Synonyms
    IGLC
  • Links
    NCBI Gene ID: 3539
    UniProt: P0DOY3

  • Chr Location
    22q11.22; chr22:22906342-22906803 (+)  GRCh38
  • Human Ortholog
    IGLC6, immunoglobulin lambda constant 6
  • Synonyms
    IGLC
  • Links
    NCBI Gene ID: 3542
    UniProt: P0CF74

  • Chr Location
    22q11.22; chr22:22919535-22919858 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-in mice homozygous for a PGK-neo insertion and a serine codon mutation show altered kappa and lambda B cell number. Knock-in mice heterozygous for the same PGK-neo insertion and a valine mutation show abnormal immunoglobulin light chain V-J joiningwhile homozygotes show reduced B cell number.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
  • All Sequences
    26
  • RefSeq
    1
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 110785 NCBI Gene Model | MGI Sequence Detail 320 C57BL/6J ±  kb
transcript M94349 GenBank | ENA | DDBJ | MGI Sequence Detail 843 SKIVE/EiJ  
polypeptide A0A0G2JE99 UniProt | EBI | MGI Sequence Detail 106 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR050160 Major Histocompatibility Complex/Immunoglobulin
Molecular
Reagents
less
  • All nucleic 32
    Genomic 21
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-16324
References
more
  • Summaries
    All 42
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:20060 Bernard O, et al., Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell. 1978 Dec;15(4):1133-44
  • Latest
    J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory