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Smarca2 Gene Detail
Summary
  • Symbol
    Smarca2
  • Name
    SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
  • Synonyms
    2610209L14Rik, brm, Snf2l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99603
    NCBI Gene: 67155
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:26582578-26755721 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 21.17 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5210 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99603
 protein coding gene Chr19:26582450-26755722 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025005
 protein coding gene Chr19:24929119-25122998 (+)
A/J MGP_AJ_G0024982
 protein coding gene Chr19:23616863-23796311 (+)
AKR/J MGP_AKRJ_G0024950
 protein coding gene Chr19:24499722-24694440 (+)
BALB/cJ MGP_BALBcJ_G0024981
 protein coding gene Chr19:23678390-23856227 (+)
C3H/HeJ MGP_C3HHeJ_G0024737
 protein coding gene Chr19:24490316-24676848 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025422
 protein coding gene Chr19:25651828-25843274 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022841
 protein coding gene Chr19:23686904-23857614 (+)
CAST/EiJ MGP_CASTEiJ_G0024207
 protein coding gene Chr19:24228145-24418041 (+)
CBA/J MGP_CBAJ_G0024715
 protein coding gene Chr19:26845624-27045297 (+)
DBA/2J MGP_DBA2J_G0024847
 protein coding gene Chr19:23605374-23784748 (+)
FVB/NJ MGP_FVBNJ_G0024809
 protein coding gene Chr19:23455381-23632994 (+)
LP/J MGP_LPJ_G0024932
 protein coding gene Chr19:24905468-25101448 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024836
 protein coding gene Chr19:26800351-26993279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025477
 protein coding gene Chr19:24523261-24713047 (+)
PWK/PhJ MGP_PWKPhJ_G0023955
 protein coding gene Chr19:23235922-23480886 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023759
 protein coding gene Chr19:23759522-24010351 (+)
WSB/EiJ MGP_WSBEiJ_G0024274
 protein coding gene Chr19:24536306-24731509 (+)



Homology
more
  • Human Ortholog
    SMARCA2, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMARCA2, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
  • Synonyms
    BAF190, BIS, BRM, hBRM, hSNF2a, NCBRS, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
  • Links
    NCBI Gene ID: 6595
    neXtProt AC: NX_P51531
    UniProt: P51531

  • Chr Location
    9p24.3; chr9:1980290-2193624 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SMARCA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation in this gene may exhibit infertility and a slightly increased body weight in some genetic backgrounds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    84
  • cDNA Data
    120
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67155 NCBI Gene Model | MGI Sequence Detail 173144 C57BL/6J ±  kb
    transcript NM_001405134 RefSeq | MGI Sequence Detail 6618 ZRU/MplStud  
    polypeptide Q6DIC0 UniProt | EBI | MGI Sequence Detail 1577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 124
      Primer pair 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16388, MGI:1914405
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 35
      Gene Ontology 35
      Phenotypes 28
    • Earliest
      J:320308 Valka I, et al., Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1. Planta Med. 1985 Aug;51(4):319-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory