Hcs6 QTL Detail

Summary

• Symbol
  Hcs6
• Name
  hepatocarcinogenesis susceptibility 6

• Feature Type
  QTL
• IDs
  MGI:99634
  NCBI Gene: 112328
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 19, 38.15 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  3
• QTL
  3
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112328

Other
Accession IDs

MGD-MRK-16419

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:20738 Manenti G, et al., Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics. 1994 Sep 1;23(1):118-24
• Latest
  J:80006 Falvella FS, et al., Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis. 2002 Nov;23(11):1933-6

Candidate Genes for Hcs6:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Scd1	Chr19:44382889-44396148 (-)	J:80006	In order to elicudate whether or not Scd1 is the gene responsible for hepatocarcinogenesis susceptibility QTL Hcs6, 179 animals from a (BALB/c x C3H/HeJ)F2 cross were typed for markers on mouse Chromosome 19 to observe the segregation of Scd1 and Hcs6. No linkage was observed, therefore the gene responsible for Hcs6 is not Scd1.