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Pola1 Gene Detail
Summary
  • Symbol
    Pola1
  • Name
    polymerase (DNA directed), alpha 1
  • Synonyms
    Pola
  • Feature Type
    protein coding gene
  • IDs
    MGI:99660
    NCBI Gene: 18968
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:92348373-92675761 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.06 cM, cytoband C-D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5410 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99660
 protein coding gene ChrX:92348372-92675993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035903
 protein coding gene ChrX:89664079-89994606 (-)
A/J MGP_AJ_G0035889
 protein coding gene ChrX:89771756-90099595 (-)
AKR/J MGP_AKRJ_G0035806
 protein coding gene ChrX:92136866-92472431 (-)
BALB/cJ MGP_BALBcJ_G0035873
 protein coding gene ChrX:88473341-88797607 (-)
C3H/HeJ MGP_C3HHeJ_G0035582
 protein coding gene ChrX:90035620-90365721 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036402
 protein coding gene ChrX:92413778-92754936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033229
 protein coding gene ChrX:87868540-88275922 (-)
CAST/EiJ MGP_CASTEiJ_G0034867
 protein coding gene ChrX:74700058-75031594 (-)
CBA/J MGP_CBAJ_G0035556
 protein coding gene ChrX:95091412-95439730 (-)
DBA/2J MGP_DBA2J_G0035712
 protein coding gene ChrX:89018008-89349417 (-)
FVB/NJ MGP_FVBNJ_G0035651
 protein coding gene ChrX:88412734-88736492 (-)
LP/J MGP_LPJ_G0035800
 protein coding gene ChrX:90443265-90785599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035685
 protein coding gene ChrX:99344705-99725514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036429
 protein coding gene ChrX:89385305-89715869 (-)
PWK/PhJ MGP_PWKPhJ_G0034566
 protein coding gene ChrX:72509007-72834556 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034396
 protein coding gene ChrX:75553974-75882179 (-)
WSB/EiJ MGP_WSBEiJ_G0035008
 protein coding gene ChrX:88180003-88515554 (-)



Homology
more
  • Human Ortholog
    POLA1, DNA polymerase alpha 1, catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLA1, DNA polymerase alpha 1, catalytic subunit
  • Synonyms
    NSX, p180, PDR, POLA, VEODS
  • Links
    NCBI Gene ID: 5422
    neXtProt AC: NX_P09884
    UniProt: P09884

  • Chr Location
    Xp22.11-p21.3; chrX:24693873-24996986 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human POLA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    74
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    61
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006678 Ensembl Gene Model | MGI Sequence Detail 327389 C57BL/6J ±  kb
transcript ENSMUST00000006856 Ensembl | MGI Sequence Detail 5346 Not Applicable  
polypeptide ENSMUSP00000006856 Ensembl | MGI Sequence Detail 1465 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012960 DNA polymerase alpha catalytic subunit
    (term hierarchy)
  • EC
    2.7.7.7
  • InterPro Domains
    IPR006172 DNA-directed DNA polymerase, family B
    IPR017964 DNA-directed DNA polymerase, family B, conserved site
    IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
    IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
    IPR045846 DNA polymerase alpha catalytic subunit, catalytic domain
    IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domain
    IPR038256 DNA polymerase alpha, zinc finger domain superfamily
    IPR042087 DNA polymerase family B, thumb domain
    IPR023211 DNA polymerase, palm domain superfamily
    IPR043502 DNA/RNA polymerase superfamily
    IPR012337 Ribonuclease H-like superfamily
    IPR036397 Ribonuclease H superfamily
    IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alpha
  • GlyGen
    P33609 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 63
    Genomic 1
    cDNA 61
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13577, MGD-MRK-16445, MGI:2148008
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:11191 Adler DA, et al., Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Genomics. 1991 Apr;9(4):642-6
  • Latest
    J:261973 Bellelli R, et al., Polepsilon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell. 2018 May 17;70(4):707-721.e7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory