Syt2 MGI Mouse Gene Detail - MGI:99666

Symbol

Syt2
Name

synaptotagmin II

Feature Type

protein coding gene
IDs

MGI:99666
NCBI Gene: 20980
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:134574319-134680887 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.24 cM
Mapping Data

4 experiments

SNPs within 2kb

3287 from dbSNP Build 142
Strain Annotations

15
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99666	protein coding gene	Chr1:134574319-134690331 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016512	protein coding gene	Chr1:138337068-138466112 (+)
A/J	MGP_AJ_G0016495	protein coding gene	Chr1:133119800-133241305 (+)
AKR/J	MGP_AKRJ_G0016460	protein coding gene	Chr1:137099043-137218668 (+)
BALB/cJ	MGP_BALBcJ_G0016455	protein coding gene	Chr1:133446111-133563591 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0016916	protein coding gene	Chr1:143370114-143492869 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014627	protein coding gene	Chr1:126246620-126362618 (+)
CAST/EiJ	MGP_CASTEiJ_G0015861	protein coding gene	Chr1:136249024-136370097 (+)
CBA/J	MGP_CBAJ_G0016254	protein coding gene	Chr1:148312851-148438189 (+)
DBA/2J	MGP_DBA2J_G0016360	protein coding gene	Chr1:132127270-132245613 (+)
FVB/NJ	MGP_FVBNJ_G0016359	protein coding gene	Chr1:130763911-130883913 (+)
LP/J	MGP_LPJ_G0016431	protein coding gene	Chr1:139599048-139722600 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016384	protein coding gene	Chr1:154013234-154139758 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016952	protein coding gene	Chr1:136833422-136952775 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0015924	protein coding gene	Chr1:136855524-136979770 (+)

Human Ortholog

SYT2, synaptotagmin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYT2, synaptotagmin 2
Synonyms

CMS7, CMS7A, CMS7B, MYSPC, SytII
Links

HGNC:11510

NCBI Gene ID: 127833

neXtProt AC: NX_Q8N9I0

UniProt: Q8N9I0
Chr Location

1q32.1; chr1:202590596-202710454 (-) GRCh38

MGI Vertebrate Homology

Syt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYT2
Gene Tree

Syt2

Diseases

2 with human SYT2 associations

				Human Disease	Mouse Models
				congenital myasthenic syndrome IDs congenital myasthenic syndrome DOID:3635 MESH:D020294 NCI:C84647 OMIM:PS601462 ORDO:590 UMLS_CUI:C0751882
				congenital myasthenic syndrome 7 IDs congenital myasthenic syndrome 7 DOID:0110659 OMIM:616040

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 4 alleles in 4 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

6
Genomic Mutations

3 involving Syt2
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele are viable but sterile, weigh less and show ataxia and altered spontaneous and Ca2+-evoked neurotransmitter release. Mice homozygous for a null allele die at weaning showing growth arrest, motor dysfunction and impaired Ca2+-evoked neurotransmitter release.

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All GO Annotations

36
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

864
Tissues

109
cDNA Data

11
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase LOC100493529

ZFIN syt2a

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All Sequences

50
RefSeq

10
UniProt

4
CCDS

CCDS15312.1

Ensembl

ENSMUSG00000026452 (Evidence)
NCBI Gene

20980

			Length	Strain/Species	Flank
genomic	20980	NCBI Gene Model \| MGI Sequence Detail	106569	C57BL/6J	± kb
transcript	NM_009307	RefSeq \| MGI Sequence Detail	7218	ZRU/MplStud
polypeptide	P46097	UniProt \| EBI \| MGI Sequence Detail	422	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015904 synaptotagmin-2

(term hierarchy)
PDB

2NP0, 4KBB
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR001565 Synaptotagmin
GlyGen

P46097 2 sites, 1 N-linked glycan (1 site)

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All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 6

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MGD-MRK-16451, MGI:2138727

Summaries

All 103

Developmental Gene Expression 28

Gene Ontology 16

Phenotypes 28
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:337770 Hu M, et al., Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. Int J Biol Sci. 2023;19(10):3226-3248

TSS for Syt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8912	Chr1:134574289-134574299 (+)	-25 bp
Tssr8913	Chr1:134574308-134574325 (+)	-2 bp
Tssr8914	Chr1:134574340-134574424 (+)	63 bp
Tssr8915	Chr1:134574439-134574449 (+)	125 bp
Tssr8916	Chr1:134574485-134574496 (+)	172 bp
Tssr8917	Chr1:134574507-134574514 (+)	192 bp
Tssr8918	Chr1:134636997-134637027 (+)	62,693 bp
Tssr8919	Chr1:134637031-134637056 (+)	62,725 bp
Tssr8920	Chr1:134637099-134637107 (+)	62,784 bp
Tssr8921	Chr1:134651152-134651156 (+)	76,835 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24