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Mug1 Gene Detail
Summary
  • Symbol
    Mug1
  • Name
    murinoglobulin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99837
    NCBI Gene: 17836
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121815500-121866016 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.52 cM, cytoband F2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1408 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99837
 protein coding gene Chr6:121815455-121866016 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0031200
 protein coding gene Chr6:119778474-119836521 (+)
C3H/HeJ MGP_C3HHeJ_G0030918
 protein coding gene Chr6:123312369-123527298 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0028818
 protein coding gene Chr6:116815820-117177362 (+)
CAST/EiJ MGP_CASTEiJ_G0030307
 protein coding gene Chr6:123674294-123892938 (+)
CBA/J MGP_CBAJ_G0030883
 protein coding gene Chr6:133103215-133250187 (+)
DBA/2J MGP_DBA2J_G0031039
 protein coding gene Chr6:118894666-119485126 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031119
 protein coding gene Chr6:124801220-125132531 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031687
 protein coding gene Chr6:123152178-123451276 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030390
 protein coding gene Chr6:123759706-123774580 (+)



Homology
more
  • Human Ortholog
    PZP, PZP alpha-2-macroglobulin like
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PZP, PZP alpha-2-macroglobulin like
  • Synonyms
    CPAMD6
  • Links
    NCBI Gene ID: 5858
    UniProt: P20742

  • Chr Location
    12p13.31; chr12:9136472-9208395 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, andincreased plasma amylase and lipase levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    22
  • cDNA Data
    133
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059908 Ensembl Gene Model | MGI Sequence Detail 50517 C57BL/6J ±  kb
    transcript ENSMUST00000032228 Ensembl | MGI Sequence Detail 4657 Not Applicable  
    polypeptide ENSMUSP00000032228 Ensembl | MGI Sequence Detail 1476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000010927 murinoglobulin-1
      (term hierarchy)
    • InterPro Domains
      IPR001599 Alpha-2-macroglobulin
      IPR011625 Alpha-2-macroglobulin, bait region domain
      IPR050473 Alpha-2-macroglobulin/Complement system
      IPR019742 Alpha-2-macroglobulin, conserved site
      IPR041813 Alpha-2-macroglobulin, TED domain
      IPR011626 Alpha-macroglobulin-like, TED domain
      IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
      IPR009048 Alpha-macroglobulin, receptor-binding
      IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002890 Macroglobulin domain
      IPR041555 Macroglobulin domain MG3
      IPR040839 Macroglobulin domain MG4
      IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
      IPR010916 TonB box, conserved site
    • GlyGen
      P28665 12 sites, 12 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 135
      Genomic 2
      cDNA 133

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16627
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:20322 Saito A, et al., Murinoglobulin, a novel protease inhibitor from murine plasma. Isolation, characterization, and comparison with murine alpha-macroglobulin and human alpha-2-macroglobulin. J Biol Chem. 1985 Jan 25;260(2):775-81
    • Latest
      J:283150 Krause K, et al., Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Front Microbiol. 2019;10:259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory