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Lama3 Gene Detail
Summary
  • Symbol
    Lama3
  • Name
    laminin, alpha 3
  • Synonyms
    [a]3B, nicein, 150kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:99909
    NCBI Gene: 16774
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:12466876-12716070 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 6.20 cM, cytoband A
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8326 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99909
 protein coding gene Chr18:12466806-12716070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024160
 protein coding gene Chr18:9502701-9779525 (+)
A/J MGP_AJ_G0024122
 protein coding gene Chr18:9338014-9588339 (+)
AKR/J MGP_AKRJ_G0024089
 protein coding gene Chr18:9628787-9880766 (+)
BALB/cJ MGP_BALBcJ_G0024121
 protein coding gene Chr18:9285859-9538058 (+)
C3H/HeJ MGP_C3HHeJ_G0023888
 protein coding gene Chr18:9500933-9764535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024566
 protein coding gene Chr18:9991785-10262102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022005
 protein coding gene Chr18:8922130-9157836 (+)
CAST/EiJ MGP_CASTEiJ_G0023365
 protein coding gene Chr18:9374162-9636114 (+)
CBA/J MGP_CBAJ_G0023860
 protein coding gene Chr18:10121373-10405394 (+)
DBA/2J MGP_DBA2J_G0023989
 protein coding gene Chr18:9181266-9429225 (+)
FVB/NJ MGP_FVBNJ_G0023954
 protein coding gene Chr18:9051434-9298034 (+)
LP/J MGP_LPJ_G0024072
 protein coding gene Chr18:9601407-9859997 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023983
 protein coding gene Chr18:10293401-10563207 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024612
 protein coding gene Chr18:9387996-9641392 (+)
PWK/PhJ MGP_PWKPhJ_G0023111
 protein coding gene Chr18:9250178-9499953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022920
 protein coding gene Chr18:9665003-9919939 (+)
WSB/EiJ MGP_WSBEiJ_G0023431
 protein coding gene Chr18:9386241-9646423 (+)



Homology
more
  • Human Ortholog
    LAMA3, laminin subunit alpha 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMA3, laminin subunit alpha 3
  • Synonyms
    BM600, E170, JEB2A, JEB2B, JEB2C, LAMNA, LOCS
  • Links
    NCBI Gene ID: 3909
    neXtProt AC: NX_Q16787
    UniProt: Q16787

  • Chr Location
    18q11.2; chr18:23689453-23956222 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Lama3 mouse models; 2 with human LAMA3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation develop a lethal blistering phenotype similar to human junctional epidermolysis bullosa, and die 2-3 days after birth from a failure to thrive.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    957
  • Tissues
    117
  • cDNA Data
    31
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024421 Ensembl Gene Model | MGI Sequence Detail 249195 C57BL/6J ±  kb
    transcript ENSMUST00000092070 Ensembl | MGI Sequence Detail 10548 Not Applicable  
    polypeptide ENSMUSP00000089703 Ensembl | MGI Sequence Detail 3330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 6
      cDNA 32
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16706
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:24448 Marinkovich MP, et al., The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol. 1992 Nov;119(3):695-703
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory