Lamc1 MGI Mouse Gene Detail - MGI:99914

Symbol

Lamc1
Name

laminin, gamma 1
Synonyms

Lamb2, laminin B2

Feature Type

protein coding gene
IDs

MGI:99914
NCBI Gene: 226519
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:153094668-153208532 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.30 cM
Mapping Data

23 experiments

SNPs within 2kb

3384 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99914	protein coding gene	Chr1:153094668-153208532 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016595	protein coding gene	Chr1:158027717-158150117 (-)
A/J	MGP_AJ_G0016577	protein coding gene	Chr1:151650576-151764723 (-)
AKR/J	MGP_AKRJ_G0016542	protein coding gene	Chr1:156349613-156473514 (-)
BALB/cJ	MGP_BALBcJ_G0016537	protein coding gene	Chr1:152220723-152336583 (-)
C3H/HeJ	MGP_C3HHeJ_G0016362	protein coding gene	Chr1:156444088-156569790 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016998	protein coding gene	Chr1:163481385-163600562 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014707	protein coding gene	Chr1:143960579-144077462 (-)
CAST/EiJ	MGP_CASTEiJ_G0015941	protein coding gene	Chr1:155952846-156080971 (-)
CBA/J	MGP_CBAJ_G0016336	protein coding gene	Chr1:169243146-169371625 (-)
DBA/2J	MGP_DBA2J_G0016442	protein coding gene	Chr1:150666133-150782187 (-)
FVB/NJ	MGP_FVBNJ_G0016440	protein coding gene	Chr1:149153982-149269825 (-)
LP/J	MGP_LPJ_G0016513	protein coding gene	Chr1:159140343-159262238 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016466	protein coding gene	Chr1:176867904-176986468 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017034	protein coding gene	Chr1:156126703-156249883 (-)
PWK/PhJ	MGP_PWKPhJ_G0015727	protein coding gene	Chr1:149693676-149809157 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015514	protein coding gene	Chr1:154923173-155058865 (-)
WSB/EiJ	MGP_WSBEiJ_G0016004	protein coding gene	Chr1:156189249-156308480 (-)

Human Ortholog

LAMC1, laminin subunit gamma 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMC1, laminin subunit gamma 1
Synonyms

LAMB2
Links

HGNC:6492

NCBI Gene ID: 3915

neXtProt AC: NX_P11047

UniProt: P11047
Chr Location

1q25.3; chr1:183023420-183145592 (+) GRCh38

MGI Vertebrate Homology

Lamc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMC1
Gene Tree

Lamc1

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Phenotype Summary

71 phenotypes from 8 alleles in 9 genetic backgrounds
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

67
Targeted

9
Genomic Mutations

2 involving Lamc1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

143 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a targeted null mutation lack development of basement membranes, migration of primitive endoderm cells out of the inner cell mass, and parietal yolk sac development, resulting in lethality by embryonic day 5.5.

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All GO Annotations

49
GO References

28

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1344
Tissues

350
cDNA Data

233
Literature Summary

114

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamc1

ZFIN lamc1

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All Sequences

56
RefSeq

2
UniProt

9
CCDS

CCDS15370.1

Ensembl

ENSMUSG00000026478 (Evidence)
NCBI Gene

226519

			Length	Strain/Species	Flank
genomic	226519	NCBI Gene Model \| MGI Sequence Detail	113865	C57BL/6J	± kb
transcript	NM_010683	RefSeq \| MGI Sequence Detail	7622	Not Specified
polypeptide	P02468	UniProt \| EBI \| MGI Sequence Detail	1607	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000009658 laminin subunit gamma-1

(term hierarchy)
PDB

1KLO, 1NPE, 1TLE, 4AQT, 5MC9
InterPro Domains

IPR000742 EGF-like domain

IPR000034 Laminin IV

IPR050440 Laminin/Netrin Extracellular Matrix

IPR008211 Laminin, N-terminal

IPR002049 Laminin-type EGF domain
GlyGen

P02468 17 sites, 38 N-linked glycans (12 sites), 1 O-linked glycan (3 sites)

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All nucleic 246

Genomic 1

cDNA 233

Primer pair 8

Other 4

Microarray probesets 5

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MGD-MRK-16712

Summaries

All 233

Developmental Gene Expression 114

Gene Ontology 28

Phenotypes 42
Earliest

J:7643 Barlow DP, et al., Sequencing of laminin B chain cDNAs reveals C-terminal regions of coiled-coil alpha-helix. EMBO J. 1984 Oct;3(10):2355-62
Latest

J:352032 Wang L, et al., ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells. iScience. 2024 Jul 19;27(7):110273

TSS for Lamc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14265	Chr1:153208767-153208774 (-)	-239 bp
Tssr14264	Chr1:153208742-153208759 (-)	-219 bp
Tssr14263	Chr1:153208706-153208713 (-)	-178 bp
Tssr14262	Chr1:153208662-153208673 (-)	-136 bp
Tssr14261	Chr1:153208631-153208640 (-)	-104 bp
Tssr14260	Chr1:153208555-153208566 (-)	-29 bp
Tssr14259	Chr1:153208470-153208550 (-)	22 bp
Tssr14258	Chr1:153208445-153208468 (-)	75 bp
Tssr14257	Chr1:153178197-153178205 (-)	30,331 bp
Tssr14256	Chr1:153138213-153138231 (-)	70,310 bp
Tssr14255	Chr1:153124847-153124893 (-)	83,662 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24